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Type: Journal article
Title: Ancient DNA
Author: Willerslev, E.
Cooper, A.
Citation: Proceedings of the Royal Society of London Series B-Biological Sciences, 2005; 272(1558):3-16
Publisher: Royal Soc London
Issue Date: 2005
ISSN: 0962-8452
Statement of
Eske Willerslev and Alan Cooper
Abstract: In the past two decades, ancient DNA research has progressed from the retrieval of small fragments of mitochondrial DNA from a few late Holocene specimens, to large-scale studies of ancient populations, phenotypically important nuclear loci, and even whole mitochondrial genome sequences of extinct species. However, the field is still regularly marred by erroneous reports, which underestimate the extent of contamination within laboratories and samples themselves. An improved understanding of these processes and the effects of damage on ancient DNA templates has started to provide a more robust basis for research. Recent methodological advances have included the characterization of Pleistocene mammal populations and discoveries of DNA preserved in ancient sediments. Increasingly, ancient genetic information is providing a unique means to test assumptions used in evolutionary and population genetics studies to reconstruct the past. Initial results have revealed surprisingly complex population histories, and indicate that modern phylogeographic studies may give misleading impressions about even the recent evolutionary past. With the advent and uptake of appropriate methodologies, ancient DNA is now positioned to become a powerful tool in biological research and is also evolving new and unexpected uses, such as in the search for extinct or extant life in the deep biosphere and on other planets.
Keywords: ancient DNA; palaeontology; palaeoecology; archaeology; population genetics; DNA damage and repair
Description: © 2005 The Royal Society Review paper
RMID: 0020065909
DOI: 10.1098/rspb.2004.2813
Appears in Collections:Earth and Environmental Sciences publications
Australian Centre for Ancient DNA publications
Environment Institute Leaders publications

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