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Type: Journal article
Title: HRT: a reappraisal of the risks and benefits
Author: MacLennan, A.
Citation: Medical Journal of Australia, 2007; 186(12):643-646
Publisher: Australasian Med Publ Co Ltd
Issue Date: 2007
ISSN: 0025-729X
Statement of
Alastair H MacLennan
Abstract: In 2002, when results of the Women's Health Initiative (WHI) randomised controlled trial of hormone replacement therapy (HRT) showed an increased occurrence of breast cancer and thromboembolism, up to two-thirds of women taking HRT stopped the therapy, often without medical consultation. Recent analyses of the WHI data and other randomised controlled trials suggest that, although there are potential side effects and risks involved in taking HRT, these may be reduced by: using lower HRT doses; minimising or eliminating systemic progestogens; using non-oral routes in some women; and initiating HRT in symptomatic women near menopause. When HRT is initiated near menopause for symptom control, there may be additional benefits (reduced fracture and cardiovascular risk) that outweigh the risks (which are not significantly raised in women under age 60 years). Older women with continuing symptoms should not be denied HRT if their therapy and risks are assessed on an individual basis and each patient is aware of the risks.
Keywords: Humans; Estrogen Replacement Therapy; Risk Assessment; Menopause; Middle Aged; Female; Randomized Controlled Trials as Topic
Description: The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.
RMID: 0020070948
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Appears in Collections:Obstetrics and Gynaecology publications

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