Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/3869
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Type: Journal article
Title: Inhibitory effects of adrenaline on the release of noradrenaline from sympathetic nerves in human dental pulp
Author: Parker, D.
Hennian, E.
Marino, V.
de la Lande, I.
Citation: Archives of Oral Biology, 1999; 44(5):391-394
Publisher: Pergamon
Issue Date: 1999
ISSN: 0003-9969
1879-1506
Statement of
Responsibility: 
D.A.S Parker, E Hennian, V Marino, I.S de la Lande
Abstract: The effects of adrenaline on the release of noradrenaline from sympathetic nerves in human dental pulp in vitro were examined. Sympathetic nerves were stimulated at 5 Hz for 100 sec following incubation of pulp with [3H]noradrenaline (0.6 micromol/l). In the presence of desipramine (DMI, 0.3 micromol/l), adrenaline (0.1 and 1.0 micromol/l) inhibited the release of [3H]noradrenaline, an effect which was inhibited by the alpha2-adrenoceptor antagonist rauwolscine (0.1 micromol/l) and by the alpha2-adrenoceptor agonist UK 14,304 (0.1 micromol/l). The release of [3H]noradrenaline was unaffected by adrenaline (0.001 and 0.01 micromol/l) in the presence of DMI and DMI plus rauwolscine. Although presynaptic inhibitory alpha2- and facilitatory beta-adrenoceptors are present on sympathetic nerves in human dental pulp, these results imply that adrenaline activates only the inhibitory alpha2-receptors.
Keywords: Human dental pulp
Sympathetic nerves
Noradrenaline
Adrenaline
α2- and β-presynaptic adrenoceptors
Rights: © 1999 Elsevier Science Ltd. All rights reserved.
DOI: 10.1016/S0003-9969(99)00015-1
Appears in Collections:Aurora harvest 6
Dentistry publications

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