Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/38706
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Type: Journal article
Title: Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium
Author: Li, H.
Bartold, P.
Young, W.
Xiao, Y.
Waters, M.
Citation: Journal of Bone and Mineral Research, 2001; 16(6):1068-1076
Publisher: Amer Soc Bone & Mineral Res
Issue Date: 2001
ISSN: 0884-0431
1523-4681
Statement of
Responsibility: 
Huika Li, P. Mark Bartold, William G. Young, Yin Xiao and Michael J. Waters
Abstract: The hypothesis that growth hormone (GH) up-regulates the expression of enzymes, matrix proteins, and differentiation markers involved in mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with GH over 5 days. The molar teeth and associated alveolar bone were processed for immunohistochemical demonstration of bone morphogenetic proteins 2 and 4 (BMP-2 and -4), bone morphogenetic protein type IA receptor (BMPR-IA), bone alkaline phosphatase (ALP), osteocalcin (OC), osteopontin (OPN), bone sialoprotein (BSP), and E11 protein (E11). The cementoblasts, osteoblasts, and periodontal ligament (PDL) cells responded to GH by expressing BMP-2 and -4, BMPR-IA, ALP, OC, and OPN and increasing the numbers of these cells. No changes were found in patterns of expression of the late differentiation markers BSP and E11 in response to GH. Thus, GH evokes expression of bone markers of early differentiation in cementoblasts, PDL cells, and osteoblasts of the periodontium. We propose that the induction of BMP-2 and -4 and their receptor by GH compliments the role of GH-induced insulin-like growth factor 1 (IGF-1) in promoting bone and tooth root formation.
Keywords: Extracellular Matrix; Periodontium; Molar; Animals; Rats, Inbred Lew; Rats; Growth Hormone; Alkaline Phosphatase; Protein-Serine-Threonine Kinases; Sialoglycoproteins; Osteocalcin; Bone Morphogenetic Proteins; Receptors, Growth Factor; Male; Bone Morphogenetic Protein Receptors, Type I; Osteopontin; Integrin-Binding Sialoprotein; Biomarkers
Rights: Copyright © 2001 by the American Society for Bone and Mineral Research
RMID: 0020064950
DOI: 10.1359/jbmr.2001.16.6.1068
Appears in Collections:Dentistry publications

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