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dc.contributor.authorCernak, I.en
dc.contributor.authorO'Connor, C.en
dc.contributor.authorVink, R.en
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 2001; 28(11):922-925en
dc.descriptionThe definitive version is available at Article first published online: 12 JAN 2002en
dc.description.abstract1. Post-traumatic inflammation may play a significant role in the development of delayed secondary brain damage following traumatic brain injury. 2. During post-traumatic inflammation, metabolic products of arachidonic acid, known as prostanoids (prostaglandins and thromboxanes) are released and aggravate the injury process. Prostanoid synthesis is regulated by the enzyme cyclo-oxygenase (COX), which is present in at least two isoforms, COX-1 (the constitutive form) and COX-2 (the inducible form). 3. In the present study, we examine the temporal and spatial profiles of COX-2 expression and the effects of the COX-2 inhibitor nimesulide on motor and cognitive outcome following diffuse traumatic brain injury in rats. 4. Adult male Sprague-Dawley rats were injured using the 2 m impact acceleration model of diffuse traumatic brain injury. At preselected time points after injury, animals were killed and the expression of COX-2 was measured in the cortex and hippocampus by western blotting techniques. 5. Increased expression of COX-2 was found in the cortex at 3 days and in the hippocampus as early as 3 h postinjury and this persisted for at least 12 days. 6. Administration of nimesulide (6 mg/kg, i.p.) at 30 min after injury and daily over a 10 day post-traumatic neurological assessment period resulted in a significant improvement compared with vehicle (2% dimethylsulphoxide diluted in isotonic saline)-treated controls in cognitive deficits, as assessed by the Barnes circular maze. There was also a significant improvement in motor dysfunction as assessed by the rotarod test on days 1 and 2 post-trauma compared with vehicle-treated controls. 7. These results implicate the involvement of COX-2 in cognitive and motor dysfunction following diffuse traumatic brain injury.en
dc.description.statementofresponsibilityI Cernak, C O'Connor, R Vinken
dc.publisherBlackwell Publishing Asiaen
dc.rightsCopyright © 2001 John Wiley & Sons, Inc. All Rights Reserved.en
dc.subjectdiffuse axonal injury; neurological outcome; neurotrauma; nimesulideen
dc.titleActivation of cyclo-oxygenase-2 contributes to motor and cognitive dysfunction following diffuse traumatic brain injury in ratsen
dc.typeJournal articleen
pubs.library.collectionAnatomical Sciences publicationsen
dc.identifier.orcidVink, R. [0000-0002-4885-0667]en
Appears in Collections:Anatomical Sciences publications

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