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Type: Patent
Title: Asparagine hydroxylation of the CAD domain of a HIF protein
Author: Whitelaw, M.
Lando, D.
Peet, D.
Gorman, J.
Karttunen, S.
Issue Date: 2002
Assignee: Adelaide Research & Innovation Pty Ltd
Abstract: A target asparagine residue of HIF 1 alpha and 2 alpha is hydroxylated at high oxygen tension to render HIF as a weak transcription factor. An asparagine hydroxylase hydroxylation motif and binding motif is proposed. A method of screening for agonists or antagonists of an asparagine hydroxylase is also proposed and involves mixing peptides or proteins having the hydroxylation and or the binding motif with asparagine hydroxylase and a candidate agonist or antagonist. The extent of inhibition or enhancement of binding; level of asparagine hydroxylation or transactivation may be measured depending on the nature of the protein or peptide. Additionally altered proteins resistant to hydroxylation are described as are nucleic acids encoding such proteins.
Description: Publication Number: WO/2003/025013; Publication Date: 27.03.2003; International Filing Date: 18.09.2002
Patent #: Int App. PCT/AU2002/001290
RMID: 0020071574
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Appears in Collections:Molecular and Biomedical Science publications

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