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dc.contributor.authorSward, K.-
dc.contributor.authorMita, M.-
dc.contributor.authorWilson, D.-
dc.contributor.authorDeng, J.-
dc.contributor.authorSusnjar, M.-
dc.contributor.authorWalsh, M.-
dc.identifier.citationCurrent Hypertension Reports, 2003; 5(1):66-72-
dc.description.abstractA variety of contractile agonists trigger activation of the small GTPase RhoA. An important target of activated RhoA in smooth muscle is Rho-associated kinase (ROK), one of the downstream targets that is the myosin binding subunit (MYPT1) of myosin light chain phosphatase (MLCP). Phosphorylation of MYPT1 at T695 by activated ROK results in a decrease in phosphatase activity of MLCP and an increase in myosin light chain (LC(20)) phosphorylation catalyzed by Ca(2)(+)/calmodulin-dependent myosin light chain kinase and/or a distinct Ca(2)(+)-independent kinase. LC(20) phosphorylation in turn triggers cross-bridge cycling and force development. ROK also phosphorylates the cytosolic protein CPI-17 (at T38), which thereby becomes a potent inhibitor of MLCP. The RhoA/ROK pathway has been implicated in the tonic phase of force maintenance in response to various agonists, with no evident role in the phasic response, suggesting this pathway as a potential target for antihypertensive therapy. Indeed, ROK inhibitors restore normal blood pressure in several rat hypertensive models.-
dc.description.statementofresponsibilityKarl Swärd, Mitsuo Mita, David P. Wilson, Jing Ti Deng, Marija Susnjar and Michael P. Walsh-
dc.publisherCurrent Science Inc.-
dc.rights© 2003 by Current Science Inc.-
dc.subjectMuscle, Smooth, Vascular-
dc.subjectrhoA GTP-Binding Protein-
dc.subjectMyosin-Light-Chain Phosphatase-
dc.subjectProtein-Serine-Threonine Kinases-
dc.subjectIntracellular Signaling Peptides and Proteins-
dc.subjectSignal Transduction-
dc.subjectMuscle Contraction-
dc.subjectPhosphoprotein Phosphatases-
dc.subjectrho-Associated Kinases-
dc.titleThe role of RhoA and Rho-associated kinase in vascular smooth muscle contraction-
dc.typeJournal article-
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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