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dc.contributor.authorTalley, N.-
dc.contributor.authorYoung, L.-
dc.contributor.authorBytzer, P.-
dc.contributor.authorHammer, J.-
dc.contributor.authorLeemon, M.-
dc.contributor.authorJones, M.-
dc.contributor.authorHorowitz, M.-
dc.identifier.citationAmerican Journal of Gastroenterology, 2001; 96(1):71-76-
dc.descriptionThe definitive version is available at
dc.description.abstractOBJECTIVES: Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life. METHODS: Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence. RESULTS: There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus.-
dc.description.statementofresponsibilityNicholas J. Talley, Lisa Young, Peter Bytzer, Johann Hammer, Melanie Leemon, Michael Jones, and Michael Horowitz-
dc.publisherBlackwell Publishing Ltd-
dc.rights© 2001 The American College of Gastroenterology-
dc.subjectGastrointestinal Diseases-
dc.subjectDiabetes Mellitus, Type 1-
dc.subjectDiabetes Mellitus, Type 2-
dc.subjectChronic Disease-
dc.subjectHealth Surveys-
dc.subjectAnalysis of Variance-
dc.subjectRisk Factors-
dc.subjectAge Distribution-
dc.subjectSex Distribution-
dc.subjectQuality of Life-
dc.subjectMiddle Aged-
dc.subjectSurveys and Questionnaires-
dc.titleImpact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life-
dc.typeJournal article-
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]-
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