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Type: Journal article
Title: Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life
Author: Talley, N.
Young, L.
Bytzer, P.
Hammer, J.
Leemon, M.
Jones, M.
Horowitz, M.
Citation: American Journal of Gastroenterology, 2001; 96(1):71-76
Publisher: Blackwell Publishing Ltd
Issue Date: 2001
ISSN: 0002-9270
Statement of
Nicholas J. Talley, Lisa Young, Peter Bytzer, Johann Hammer, Melanie Leemon, Michael Jones, and Michael Horowitz
Abstract: OBJECTIVES: Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life. METHODS: Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence. RESULTS: There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus.
Keywords: Humans
Gastrointestinal Diseases
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Chronic Disease
Health Surveys
Analysis of Variance
Risk Factors
Age Distribution
Sex Distribution
Quality of Life
Middle Aged
Surveys and Questionnaires
Description: The definitive version is available at
Rights: © 2001 The American College of Gastroenterology
DOI: 10.1111/j.1572-0241.2001.03350.x
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