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https://hdl.handle.net/2440/39230
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dc.contributor.author | Takahashi, Y. | - |
dc.contributor.author | Hocini, M. | - |
dc.contributor.author | O'Neill, M. | - |
dc.contributor.author | Sanders, P. | - |
dc.contributor.author | Rotter, M. | - |
dc.contributor.author | Rostock, T. | - |
dc.contributor.author | Jonsson, A. | - |
dc.contributor.author | Sacher, F. | - |
dc.contributor.author | Clementy, J. | - |
dc.contributor.author | Jais, P. | - |
dc.contributor.author | Haissaguerre, M. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Journal of the American College of Cardiology, 2006; 47(10):2005-2012 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.issn | 1558-3597 | - |
dc.identifier.uri | http://hdl.handle.net/2440/39230 | - |
dc.description | © 2006 by the American College of Cardiology Foundation. Published by Elsevier Inc. | - |
dc.description.abstract | <h4>Objectives</h4>The aim of the present study was to assess the feasibility of identifying sites of focal atrial activity by localized high-density endocardial mapping during atrial fibrillation (AF).<h4>Background</h4>Sites of focal activity in the left atrium have been demonstrated by epicardial mapping during AF.<h4>Methods</h4>Twenty-four patients (15 with paroxysmal, 3 with persistent, and 6 with permanent AF) underwent endocardial mapping during AF. A 20-pole catheter with five radiating spines was used to map both atria for 30 s in each of 10 pre-determined segments. A focal activity was defined as > or =3 atrial cycles with activation spreading from center to periphery of the mapping catheter. Catheter ablation was performed independent of the mapping results.<h4>Results</h4>Spontaneous focal activities were observed in 13 sites in the left atrium (9%; anterior 1, roof 2, posterior 6, inferior 4) in 12 patients (9 paroxysmal, 3 persistent). Focal activity was observed continuously (two sites) or intermittently (11 sites, median 5 episodes), and associated with shortening of the cycle length (from 183 +/- 33 ms to 172 +/- 29 ms; p < 0.05). The mean duration of an intermittent episode was 1.5 s (range 0.4 to 7.1 s). Atrial fibrillation terminated without ablation at the foci in all of 12 patients, but in 2 of them, re-initiated arrhythmia was successfully ablated at these foci. Nine of these 12 patients (75%) were arrhythmia-free without antiarrhythmic drugs during a follow-up period of 7.0 +/- 3.1 months.<h4>Conclusions</h4>Termination of AF without ablation at the sites of atrial focal activity suggests that this activity may be triggered by impulses originating from other regions, such as the pulmonary veins. | - |
dc.description.statementofresponsibility | Yoshihide Takahashi, Mélèze Hocini, Mark D. O’Neill, Prashanthan Sanders, Martin Rotter, Thomas Rostock, Anders Jonsson, Frédéric Sacher, Jacques Clémenty, Pierre Jaïs and Michel Haïssaguerre | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jacc.2005.12.068 | - |
dc.subject | Pulmonary Veins | - |
dc.subject | Endocardium | - |
dc.subject | Heart Atria | - |
dc.subject | Humans | - |
dc.subject | Atrial Fibrillation | - |
dc.subject | Anti-Arrhythmia Agents | - |
dc.subject | Electrocardiography | - |
dc.subject | Electrophysiologic Techniques, Cardiac | - |
dc.subject | Catheter Ablation | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Feasibility Studies | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Sites of focal atrial activity characterized by endocardial mapping during atrial fibrillation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jacc.2005.12.068 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Sanders, P. [0000-0003-3803-8429] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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