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Type: Journal article
Title: Etiology of preeclampsia: an update
Author: Dekker, G.
Sukcharoen, N.
Citation: Journal of the Medical Association of Thailand, 2004; 87(Suppl 3):S96-S103
Publisher: Medical Association of Thailand
Issue Date: 2004
ISSN: 0125-2208
Abstract: Preeclampsia still ranks as one of obstetrics major problems. Clinicians typically encounter preeclampsia as maternal disease with variable degrees of fetal involvement. More and more the unique immunogenetic maternal - paternal relationship is appreciated, and as such also the specific ‘genetic conflict’ that is characteristic of haemochorial placentation. Factors influencing the unique maternal-fetal (paternal) interaction probably include the length and type of sexual relationship, the maternal (decidual natural killer cells) acceptation of the invading cytotrophoblast (paternal HLA-C), and seminal levels of transforming growth factor-b and probably other cytokines. The magnitude of the maternal response would be determined by factors including a maternal set of genes determining her characteristic inflammatory responsiveness, age, quality of her endothelium, obesity/ insulin resistance and probably a whole series of susceptibility genes amongst which the thrombophilias received a lot of attention in recent years.
Keywords: Etiology; Preeclampsia
Rights: © Medical Association of Thailand
RMID: 0020072052
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Appears in Collections:Obstetrics and Gynaecology publications

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