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Type: Journal article
Title: Growth-hormone-stimulated dentinogenesis in Lewis dwarf rat molars
Author: Young, W.
Li, H.
Xiao, Y.
Waters, M.
Bartold, P.
Citation: Journal of Dental Research, 2001; 80(8):1742-1747
Publisher: Inter Amer Assoc Dental Research
Issue Date: 2001
ISSN: 0022-0345
Statement of
W. G. Young, H. Li, Y. Xiao, M. J. Waters and P. M. Bartold
Abstract: In dentinogenesis, certain growth factors, matrix proteoglycans, and proteins are directly or indirectly dependent on growth hormone. The hypothesis that growth hormone up-regulates the expression of enzymes, sialoproteins, and other extracellular matrix proteins implicated in the formation and mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with growth hormone over 5 days. The molar teeth were processed for immunohistochemical demonstration of bone-alkaline phosphatase, bone morphogenetic proteins-2 and -4, osteocalcin, osteopontin, bone sialoprotein, and E11 protein. Odontoblasts responded to growth hormone by more cells expressing bone morphogenetic protein, alkaline phosphatase, osteocalcin, and osteopontin. No changes were found in bone sialoprotein or E11 protein expression. Thus, growth hormone may stimulate odontoblasts to express several growth factors and matrix proteins associated with dentin matrix biosynthesis in mature rat molars.
Keywords: Bone Matrix; Odontoblasts; Molar; Animals; Rats, Inbred Strains; Rats, Inbred Lew; Rats; Growth Hormone; Alkaline Phosphatase; Transforming Growth Factor beta; Sialoglycoproteins; Osteocalcin; Bone Morphogenetic Proteins; Phosphoproteins; Extracellular Matrix Proteins; Antibodies, Monoclonal; Immunohistochemistry; Analysis of Variance; Up-Regulation; Calcification, Physiologic; Tooth Calcification; Osteogenesis; Dentinogenesis; Osteopontin; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Integrin-Binding Sialoprotein
Rights: Copyright © 2001 by International & American Associations for Dental Research Online Journals
RMID: 0020071912
DOI: 10.1177/00220345010800081201
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Appears in Collections:Dentistry publications

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