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|Title:||Growth-hormone-stimulated dentinogenesis in Lewis dwarf rat molars|
|Citation:||Journal of Dental Research, 2001; 80(8):1742-1747|
|Publisher:||Inter Amer Assoc Dental Research|
|W. G. Young, H. Li, Y. Xiao, M. J. Waters and P. M. Bartold|
|Abstract:||In dentinogenesis, certain growth factors, matrix proteoglycans, and proteins are directly or indirectly dependent on growth hormone. The hypothesis that growth hormone up-regulates the expression of enzymes, sialoproteins, and other extracellular matrix proteins implicated in the formation and mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with growth hormone over 5 days. The molar teeth were processed for immunohistochemical demonstration of bone-alkaline phosphatase, bone morphogenetic proteins-2 and -4, osteocalcin, osteopontin, bone sialoprotein, and E11 protein. Odontoblasts responded to growth hormone by more cells expressing bone morphogenetic protein, alkaline phosphatase, osteocalcin, and osteopontin. No changes were found in bone sialoprotein or E11 protein expression. Thus, growth hormone may stimulate odontoblasts to express several growth factors and matrix proteins associated with dentin matrix biosynthesis in mature rat molars.|
|Keywords:||Bone Matrix; Odontoblasts; Molar; Animals; Rats, Inbred Strains; Rats, Inbred Lew; Rats; Growth Hormone; Alkaline Phosphatase; Transforming Growth Factor beta; Sialoglycoproteins; Osteocalcin; Bone Morphogenetic Proteins; Phosphoproteins; Extracellular Matrix Proteins; Antibodies, Monoclonal; Immunohistochemistry; Analysis of Variance; Up-Regulation; Calcification, Physiologic; Tooth Calcification; Osteogenesis; Dentinogenesis; Osteopontin; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Integrin-Binding Sialoprotein|
|Rights:||Copyright © 2001 by International & American Associations for Dental Research Online Journals|
|Appears in Collections:||Dentistry publications|
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