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Type: Journal article
Title: Toxicity of environmental lead and the influence of intestinal absorption in children
Author: Heath, L.
Soole, K.
McLaughlin, M.
McEwan, G.
Edwards, J.
Citation: Reviews on Environmental Health, 2003; 18(4):231-250
Publisher: Freund Publishing House, Ltd.
Issue Date: 2003
ISSN: 0048-7554
Statement of
L.M. Heath, K.L. Soole, M. McLaughlin, G.T.A. McEwan, J.W. Edwards
Abstract: Exposure to metals, particularly lead, remains a widespread issue that is associated with historical and current industrial practices. Whereas the toxic properties of metals are well described, exposure to metals per se is only one of many factors contributing to elevated blood metal concentrations and their consequent health effects in humans. The absorbed dose of metal is affected by geochemical, biochemical, and physiological parameters that influence the rate and extent of absorption. In children, the interplay among these factors can be of critical importance, especially when biochemical and physiological processes might not have matured to their normal adult status. Such immaturity represents an elevated risk to metal-exposed children because they might be more susceptible to enhanced absorption, especially via the oral route. This review brings together the more recent findings on the physiological mechanisms of metal absorption, especially lead, and examines several models that can be useful in assessing the potential for metal uptake in children.
Keywords: Bioavailability; enterocyte; heavy metals; In vitro; In vivo; lead; review; toxicokinetics
Description: © Freund Publishing House
RMID: 0020071888
DOI: 10.1515/REVEH.2003.18.4.231
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Appears in Collections:Civil and Environmental Engineering publications
Environment Institute publications

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