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Type: Journal article
Title: Ibudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
Author: Ledeboer, A.
Hutchinson, M.
Watkins, L.
Johnson, K.
Citation: Expert Opinion on Investigational Drugs, 2007; 16(7):935-950
Publisher: Ashley Publications Ltd
Issue Date: 2007
ISSN: 1354-3784
Abstract: The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially contribute to neuropathic pain as well as opioid dependence and withdrawal, the authors conceived that ibudilast may be useful for treating these conditions. Preclinical data indicate that ibudilast crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action.
Keywords: analgesia; astroglia; cytokine; ibudilast; microglia; neuropathic pain; opioids; phosphodiesterase inhibitor; withdrawal
Description: © 2007 Informa UK Limited
RMID: 0020071177
DOI: 10.1517/13543784.16.7.935
Appears in Collections:Medical Sciences publications

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