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dc.contributor.authorLedeboer, A.en
dc.contributor.authorHutchinson, M.en
dc.contributor.authorWatkins, L.en
dc.contributor.authorJohnson, K.en
dc.identifier.citationExpert Opinion on Investigational Drugs, 2007; 16(7):935-950en
dc.description© 2007 Informa UK Limiteden
dc.description.abstractThe treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially contribute to neuropathic pain as well as opioid dependence and withdrawal, the authors conceived that ibudilast may be useful for treating these conditions. Preclinical data indicate that ibudilast crosses the blood-brain barrier, is well tolerated, is active on oral administration, reduces glial activation and attenuates pain symptoms in diverse rat models of neuropathic pain. In addition, it enhances acute morphine analgesia and attenuates morphine tolerance and withdrawal. Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action.en
dc.format.extent3033625 bytesen
dc.publisherAshley Publications Ltden
dc.subjectanalgesia; astroglia; cytokine; ibudilast; microglia; neuropathic pain; opioids; phosphodiesterase inhibitor; withdrawalen
dc.titleIbudilast (AV-411): A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromesen
dc.typeJournal articleen
pubs.library.collectionMedical Sciences publicationsen
Appears in Collections:Medical Sciences publications

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