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Type: Conference paper
Title: Neuroprotective effects of sAPPα administration following diffuse traumatic brain injury
Other Titles: Neuroprotective effects of sAPPalpha administration following diffuse traumatic brain injury
Author: Van Den Heuvel, C.
Thornton, E.
Blumbergs, P.
Rodgers, K.
Vink, R.
Citation: 7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.145-149
Publisher: Medimond International Proceedings
Publisher Place: Bologna Italy
Issue Date: 2004
ISBN: 88-7587-082-9
Conference Name: International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.)
Statement of
C. Van Den Heuvel, E. Thornton, P.C. Blumbergs, K.R. Rodgers and R. Vink
Abstract: Soluble amyloid precursor protein α (sAPPα) is a product of the nonamyloidogenic cleavage pathway of APP that has previously been shown to have many neuroprotective functions in vitro. No study, however, has addressed whether sAPPα may also be neuroprotective in vivo. The present study has therefore examined the in vivo effects of sAPPα administration on axonal injury and neurological outcome following 2- metre impact/ acceleration traumatic brain injury in rats. Treatment with sAPPα at 30 min after injury (icv) significantly reduced axonal injury (AI) within the corpus callosum at 1, 3 and 7 days post-injury and significantly improved motor outcome (rotarod) compared to vehicle treated controls. Our results demonstrate the in vivo neuroprotective properties of post-traumatic administration of sAPPα following traumatic brain injury.
Description: The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included.
Rights: Copyright © 2004 by MEDIMOND
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Pathology publications

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