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Type: Conference paper
Title: Inhibition of neurogenic inflammation attenuates the inflammatory response following traumatic brain injury in rats
Author: Reardon, K.
Heath, D.
Nimmo, A.
Vink, R.
Whitfield, K.
Citation: 7th International Neurotrauma Symposium, Adelaide, Australia, 12-16 September, 2004: pp.115-118
Publisher: Medimond International Proceedings
Publisher Place: Bologna, Italy
Issue Date: 2004
ISBN: 88-7587-082-9
Conference Name: International Neurotrauma Symposium (7th : 2004 : Adelaide, S. Aust.)
Statement of
K. Reardon, D. Heath, A. Nimmo, R. Vink and K. Whitfield
Abstract: A profound inflammatory response is initiated following traumatic brain injury (TBI). It has been proposed that serum IL-6 levels may serve as a marker for the severity of the injury. Using the rat impact-acceleration model of TBI, the study examined whether drugs which are able to inhibit neurogenic inflammation (capsaicin, NK1 antagonist), might influence the post-traumatic inflammatory response. In non-treated animals, TBI resulted in a significant increase in serum IL-6 levels. However, in animals pre-treated with capsaicin prior to injury, or treated with an NK1 antagonist following injury, this rise in IL-6 levels was not observed. We conclude that the inhibition of neurogenic inflammation may attenuate the inflammatory reaction associated with TBI, and help improve outcome.
Description: © 2004 by MEDIMOND The document attached has been archived with permission from the Medimond International Proceedings Division. An external link to the publisher’s web site is included.
RMID: 0020075397
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Appears in Collections:Pathology publications

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