Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/4153
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Type: Journal article
Title: Role of medical history in brain tumor development. Results fromthe international adult brain tumour study
Author: Schlehofer, B.
Blettner, M.
Preston-Martin, S.
Niehoff, D.
Wahrendorf, J.
Arslan, A.
Ahlbom, A.
Choi, W.
Giles, G.
Howe, G.
Little, J.
Menegoz, F.
Ryan, P.
Citation: International Journal of Cancer, 1999; 82(2):155-160
Publisher: WILEY
Issue Date: 1999
ISSN: 0020-7136
1097-0215
Statement of
Responsibility: 
Brigitte Schlehofer, Maria Blettner, Susan Preston-Martin, Dorothea Niehoff, Jürgen Wahrendorf, Annie Arslan, Anders Ahlbom, Won N. Choi, Graham G. Giles, Geoffrey R. Howe, Julian Little, Francois Ménégoz, Philip Ryan
Abstract: In an international population-based case-control study carried out in 8 centres in 6 countries, we investigated the role of specific medical conditions in the aetiology of brain tumours in adults. Recruited were 1,178 glioma and 331 meningioma cases and 2,493 age- and gender-matched population controls. Only medical conditions occurring at least 2 years before brain tumour diagnosis were considered. Relative risks (RRs) and 95% confidence intervals (CIs) were estimated using a conditional logistic regression model. Heterogeneity between centres was tested. No association between meningioma and previous medical conditions was observed. For glioma, there was an increased risk associated with epilepsy (RR = 6.55, 95% CI 3.40-12.63), but this was considerably weaker for epilepsy of more than 20 years duration. The risk remained elevated after adjustment for use of anti-epileptic drugs. There was a statistically significant inverse association between glioma and all allergic diseases combined (RR = 0.59, 95% CI 0.49-0.71); this was also observed for specific allergic conditions, namely, asthma and eczema. Subjects who reported a history of infectious diseases (e.g., colds, flu) showed a 30% reduction in risk (RR = 0.72, 95% CI 0.61-0.85). The decreased risks for glioma in subjects reporting a history of allergic conditions or infectious diseases may indicate an influence of immunological factors on the development of glioma. The association between glioma and epilepsy has to be interpreted cautiously and needs further investigation.
Keywords: Humans
Glioma
Meningioma
Brain Neoplasms
Nervous System Diseases
Epilepsy
Genetic Diseases, Inborn
Hypersensitivity
Contraceptives, Oral, Hormonal
Anticonvulsants
Anti-Allergic Agents
Reproductive History
Hormone Replacement Therapy
Risk
Risk Factors
Case-Control Studies
Retrospective Studies
Mental Disorders
Comorbidity
Adult
Aged
Aged, 80 and over
Middle Aged
Drug Utilization
Female
Male
Surveys and Questionnaires
Infections
DOI: 10.1002/(SICI)1097-0215(19990719)82:2<155::AID-IJC1>3.0.CO;2-P
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