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https://hdl.handle.net/2440/41969
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dc.contributor.author | Karamanlis, A. | - |
dc.contributor.author | Chaikomin, R. | - |
dc.contributor.author | Doran, S. | - |
dc.contributor.author | Bellon, M. | - |
dc.contributor.author | Bartholomeusz, D. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2007; 86(5):1364-1368 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/41969 | - |
dc.description | © 2007 American Society for Nutrition | - |
dc.description.abstract | <h4>Background</h4>Dietary interventions represent a promising therapeutic strategy to optimize postprandial glycemia. The addition of protein to oral glucose has been reported to improve the glycemic profile.<h4>Objective</h4>The aim of the current study was to evaluate the mechanisms by which protein supplementation lowers the blood glucose response to oral glucose.<h4>Design</h4>Nine healthy men were studied on 3 d each in a random order. Subjects consumed 300-mL drinks containing either 50 g glucose (Glucose), 30 g gelatin (Protein), or 50 g glucose with 30 g gelatin (Glucose + Protein) in water labeled with 150 mg [(13)C]acetate. Blood and breath samples were subsequently collected for 3 h to measure blood glucose and plasma insulin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) concentrations and gastric half-emptying time, which was calculated from (13)CO(2) excretion.<h4>Results</h4>The blood glucose response was less after Glucose + Protein than after Glucose (P < 0.005); GIP was lower (P < 0.005), and there were no significant differences in plasma insulin or GLP-1. Protein alone stimulated insulin, GLP-1, and GIP (P < 0.05 for each) without elevating blood glucose. The gastric half-emptying time was greater after Glucose + Protein than after Glucose (P < 0.05) and tended to be greater for Glucose than for Protein (P = 0.06).<h4>Conclusions</h4>In healthy humans, the addition of protein to oral glucose lowers postprandial blood glucose concentrations acutely, predominantly by slowing gastric emptying, although protein also stimulates incretin hormones and non-glucose-dependent insulin release. | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.source.uri | http://www.ajcn.org/cgi/content/abstract/86/5/1364 | - |
dc.subject | Humans | - |
dc.subject | Insulin | - |
dc.subject | Glucose | - |
dc.subject | Blood Glucose | - |
dc.subject | Dietary Proteins | - |
dc.subject | Administration, Oral | - |
dc.subject | Gastric Emptying | - |
dc.subject | Adult | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.subject | Incretins | - |
dc.title | Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/86.5.1364 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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