Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/42059
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Type: Journal article
Title: Effects of perhexiline and nitroglycerin on vascular, neutrophil and platelet function in patients with stable angina pectoris
Author: Liberts, E.
Willoughby, S.
Kennedy, J.
Horowitz, J.
Citation: Behavioural Processes, 2007; 560(1):49-55
Publisher: Elsevier Science BV
Issue Date: 2007
ISSN: 0014-2999
1879-0712
Statement of
Responsibility: 
Elizabeth A. Liberts, Scott R. Willoughby, Jennifer A. Kennedy, John D. Horowitz
Abstract: Perhexiline, a "metabolic" anti-anginal agent currently under investigation in management of congestive heart failure and acute coronary syndromes improves platelet nitric oxide responsiveness in patients with impaired responsiveness. The current study investigated possible interactions between perhexiline and the nitric oxide donor nitroglycerin on arterial stiffness, neutrophil superoxide release and on platelet nitric oxide responsiveness. Patients (n=39) with stable angina pectoris, awaiting cardiac catheterization were randomized to additional perhexiline or unchanged drug therapy; all patients received nitroglycerin infusion for 2 h. Vasomotor responses to perhexiline and combined perhexiline/nitroglycerin were examined using changes in augmentation index, measured via applanation tonometry. Neutrophil superoxide release was measured ex vivo utilizing lucigenin mediated chemiluminescence and effect of perhexiline on inhibition of platelet aggregation by sodium nitroprusside was also measured. Perhexiline alone did not affect augmentation index, neutrophil superoxide release, or ex vivo platelet sodium nitroprusside response. Nitroglycerin decreased augmentation index (P<0.01) and superoxide release (P<0.05). Magnitude of inhibition of superoxide release was significantly enhanced by perhexiline pre-treatment (P<0.05); however perhexiline had no effect on magnitude of vasomotor response to nitroglycerin. In conclusion, perhexiline exerts no effects on arterial stiffness and does not potentiate nitroglycerin induced dilatation. In patients with normal platelet function perhexiline does not affect platelet nitric oxide responsiveness. In vivo low dose nitroglycerin inhibits neutrophil superoxide release; this effect is potentiated by pre-treatment with perhexiline. These "anti-inflammatory" effects of nitroglycerin may contribute to utility in acute coronary syndromes and congestive heart failure.
Keywords: Arteries
Neutrophils
Humans
Angina Pectoris
Superoxides
Nitroglycerin
Perhexiline
Vasodilator Agents
Platelet Function Tests
Manometry
Platelet Aggregation
Drug Interactions
Middle Aged
Female
Male
Luminescence
Cardiovascular Physiological Phenomena
Description: Copyright © 2007 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.ejphar.2007.01.001
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description#description
Appears in Collections:Aurora harvest
Medicine publications

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