Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/42240
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dc.contributor.authorLittle, T.en
dc.contributor.authorRusso, A.en
dc.contributor.authorMeyer, J.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorSmyth, D.en
dc.contributor.authorBellon, M.en
dc.contributor.authorWishart, J.en
dc.contributor.authorJones, K.en
dc.contributor.authorFeinle-Bisset, C.en
dc.date.issued2007en
dc.identifier.citationGastroenterology, 2007; 133(4):1124-1131en
dc.identifier.issn0016-5085en
dc.identifier.issn1528-0012en
dc.identifier.urihttp://hdl.handle.net/2440/42240-
dc.descriptionCopyright © 2007 AGA Institute Published by Elsevier Inc.en
dc.description.abstractBACKGROUND & AIMS: The effects of fat on gastric emptying (GE), gut hormones, and energy intake are dependent on digestion to free fatty acids (FFAs). In animals, small intestinal oleic acid inhibits energy intake more potently than the triacylglyceride (TG) triolein, but there is limited information about the comparative effects of FFA and TG in human beings. We compared the effects of FFA and TG on GE, gut hormone secretion, appetite, and energy intake in healthy males. METHODS: Nine men (age, 23 +/- 2 y; body mass index, 22 +/- 1 kg/m(2)) were studied on 3 occasions to evaluate the effects of (1) 40 g oleic acid (FFA, 1830 kJ), (2) 40 g macadamia oil (TG, 1856 kJ; both 600-mL oil-in-water emulsions stabilized with 4% milk protein and labeled with 15 MBq (123)I), or (3) 600 mL 4% milk protein (control, 352 kJ), administered intragastrically, on GE, plasma cholecystokinin (CCK) and peptide-YY (PYY) levels, appetite perceptions, and subsequent energy intake. RESULTS: GE of FFA was much slower than that of TG (P < .05), with greater retention of FFA, than TG, in the proximal stomach (P < .001). Hunger was less (P < .05), and fullness was greater (P < .05), after FFA when compared with control and TG. Increases in plasma CCK and PYY levels were greater after FFA than TG or control (P < .05). Energy intake tended to be less after FFA compared with TG (control, 4754 +/- 610 kJ; TG, 5463 +/- 662 kJ; FFA, 4199 +/- 410 kJ). CONCLUSIONS: FFAs empty from the stomach more slowly, but stimulate CCK and PYY and suppress appetite more potently than TG in healthy human beings.en
dc.description.statementofresponsibilityTanya J. Little, Antonietta Russo, James H. Meyer, Michael Horowitz, Douglas R. Smyth‡, Max Bellon‡, Judith M. Wishart, Karen L. Jones and Christine Feinle-Bisseten
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623297/description#descriptionen
dc.language.isoenen
dc.publisherW B Saunders Coen
dc.subjectGastrointestinal Tract; Humans; Macadamia; Gastrointestinal Hormones; Cholecystokinin; Peptide YY; Fatty Acids, Nonesterified; Oleic Acid; Triglycerides; Plant Oils; Milk Proteins; Appetite Depressants; Gastrointestinal Transit; Administration, Oral; Double-Blind Method; Appetite; Energy Intake; Gastric Emptying; Time Factors; Reference Values; Beverages; Adult; Maleen
dc.titleFree fatty acids have more potent effects on gastric emptying, gut hormones, and appetite than triacylglyceridesen
dc.typeJournal articleen
dc.identifier.rmid0020073211en
dc.identifier.doi10.1053/j.gastro.2007.06.060en
dc.identifier.pubid47200-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidLittle, T. [0000-0001-9814-1036]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
Appears in Collections:Medicine publications

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