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|Title:||The use of a “Liquid” electrode in hepatic electrolysis|
|Citation:||Journal of Surgical Research, 2004; 120(2):272-277|
|Publisher:||Academic Press Inc Elsevier Science|
|J. Guy Finch, Beverley G. Fosh, Adrian A. Anthony, Michael Texler, Susan Pearson, Ashley R. Dennison and Guy J. Maddern|
|Abstract:||Background: The use of direct current electrolysis as a local nonthermal ablative technique for colorectal liver metastases promises to be a simple, safe, and effective therapy. Under general anesthesia, electrolysis is presently limited to tumors smaller than 5 cm, due to the protracted nature of its administration. In an attempt to enhance the effect of electrolysis, a direct current was passed through a preinjected bolus of acetic acid. Methods: The effect of a combination of electrolysis and an injection of acetic acid was tested in the liver of eight normal pigs. The volumes of necrosis caused were analyzed. Results: Acetic acid independently produced a volume of necrosis but did not provide a volumetric or rate advantage when used in combination with a direct current. Statistically, the only main effect on the volume of necrosis was a result of electrolysis. Conclusion: The use of 50% acetic acid to augment the efficacy of direct current electrolysis cannot be recommended.|
|Keywords:||Acetic acid; colorectal liver metastases; electrochemical therapy; electrolysis; porcine model|
|Description:||Copyright © 2004 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Surgery publications|
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