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Type: Journal article
Title: The use of a “Liquid” electrode in hepatic electrolysis
Author: Finch, G.
Fosh, B.
Anthony, A.
Texler, M.
Pearson, S.
Dennison, A.
Maddern, G.
Citation: Journal of Surgical Research, 2004; 120(2):272-277
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2004
ISSN: 0022-4804
Statement of
J. Guy Finch, Beverley G. Fosh, Adrian A. Anthony, Michael Texler, Susan Pearson, Ashley R. Dennison and Guy J. Maddern
Abstract: Background: The use of direct current electrolysis as a local nonthermal ablative technique for colorectal liver metastases promises to be a simple, safe, and effective therapy. Under general anesthesia, electrolysis is presently limited to tumors smaller than 5 cm, due to the protracted nature of its administration. In an attempt to enhance the effect of electrolysis, a direct current was passed through a preinjected bolus of acetic acid. Methods: The effect of a combination of electrolysis and an injection of acetic acid was tested in the liver of eight normal pigs. The volumes of necrosis caused were analyzed. Results: Acetic acid independently produced a volume of necrosis but did not provide a volumetric or rate advantage when used in combination with a direct current. Statistically, the only main effect on the volume of necrosis was a result of electrolysis. Conclusion: The use of 50% acetic acid to augment the efficacy of direct current electrolysis cannot be recommended.
Keywords: Acetic acid; colorectal liver metastases; electrochemical therapy; electrolysis; porcine model
Description: Copyright © 2004 Elsevier Inc. All rights reserved.
RMID: 0020040574
DOI: 10.1016/j.jss.2004.03.019
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Appears in Collections:Surgery publications

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