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Type: Journal article
Title: Design of endoperoxides with anti-Candida activity
Author: Avery, T.
Macreadie, P.
Greatrex, B.
Robinson, A.
Taylor, D.
Macreadie, I.
Citation: Bioorganic & Medicinal Chemistry, 2007; 15(1):36-42
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2007
ISSN: 0968-0896
Statement of
Thomas D. Avery, Peter I. Macreadie, Ben W. Greatrex, Tony V. Robinson, Dennis K. Taylor, and Ian G. Macreadie
Abstract: Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.
Keywords: Artemisinin
Description: Available online 13 October 2006
RMID: 0020070020
DOI: 10.1016/j.bmc.2006.10.021
Appears in Collections:Chemistry publications

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