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|Title:||Design of endoperoxides with anti-Candida activity|
|Citation:||Bioorganic & Medicinal Chemistry, 2007; 15(1):36-42|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Thomas D. Avery, Peter I. Macreadie, Ben W. Greatrex, Tony V. Robinson, Dennis K. Taylor, and Ian G. Macreadie|
|Abstract:||Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.|
|Description:||Available online 13 October 2006|
|Appears in Collections:||Chemistry publications|
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