Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/42817
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Type: Journal article
Title: Effect of omeprazole on acid gastroesophageal reflux and gastric acidity in preterm infants with pathological acid reflux
Author: Omari, T.
Haslam, R.
Lundborg, P.
Davidson, G.
Citation: Journal of Pediatric Gastroenterology and Nutrition, 2007; 44(1):41-44
Publisher: Lippincott Williams & Wilkins
Issue Date: 2007
ISSN: 0277-2116
1536-4801
Abstract: ntroduction: Proton pump inhibitor (PPI) therapy is increasingly being used to treat premature infants with gastroesophageal reflux disease (GERD); however, the efficacy of PPI on acid production in this population has yet to be assessed in this patient group. The aim of this study was to determine the effect of 0.7 mg/kg/d omeprazole on gastric acidity and acid gastroesophageal reflux in preterm infants with reflux symptoms and pathological acid reflux on 24-h pH probe. Methods: A randomized, double blind, placebo-controlled, crossover design trial of omeprazole therapy was performed in 10 preterm infants (34-40 weeks postmenstrual age). Infants were given omeprazole for 7 d and then placebo for 7 d in randomized order. Twenty-four-hour esophageal and gastric pH monitoring was performed on days 7 and 14 of the trial. Results: Compared to placebo, omeprazole therapy significantly reduced gastric acidity (%time pH <4, 54% vs 14%, P < 0.0005), esophageal acid exposure (%time pH <4, 19% vs 5%, P < 0.01) and number of acid GER episodes (119 vs 60 episodes, P < 0.05). Conclusions: Omeprazole is effective in reducing esophageal acid exposure in premature infants with pathological acid reflux on 24-h pH probe; however, the far more complex issues of safety and efficacy have yet to be addressed.
Keywords: Gastric Acid; Humans; Gastroesophageal Reflux; Omeprazole; Anti-Ulcer Agents; Gastric Acidity Determination; Cross-Over Studies; Double-Blind Method; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Infant, Premature; Esophageal pH Monitoring; Proton Pump Inhibitors
RMID: 0020070023
DOI: 10.1097/01.mpg.0000252190.97545.07
Published version: http://journals.lww.com/jpgn/Fulltext/2007/01000/Effect_of_Omeprazole_on_Acid_Gastroesophageal.10.aspx
Appears in Collections:Paediatrics publications

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