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|Title:||Gingival crevicular fluid interleukin-1β, prostaglandin E₂and periodontal status in a community population|
|Other Titles:||Gingival crevicular fluid interleukin-1beta, prostaglandin E(2)and periodontal status in a community population|
|Citation:||Journal of Clinical Periodontology, 2007; 34(4):285-293|
|Y. Zhong, G. D. Slade, J. D. Beck and S. Offenbacher|
|Abstract:||Aim: Interleukin-1 β (IL-1β) and prostaglandin E2 (PGE2) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1β and PGE2 in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. Material and Methods: The sample comprised 6277 community-dwelling adults aged 52–74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1β and PGE2 concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1β and PGE2 concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. Results: Both GCF IL-1β and PGE2 were positively related to MaxPD and BOP in multiple regression models (p<0.01). Increased levels of IL-1β and PGE2 were associated with body mass index 30 kg/m2. Conclusion: Higher levels of GCF IL-1β and PGE2 were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults.|
|Keywords:||Gingival Crevicular Fluid|
Body Mass Index
|Description:||The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Aurora harvest 6|
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