Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/43081
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhong, Y. | - |
dc.contributor.author | Slade, G. | - |
dc.contributor.author | Beck, J. | - |
dc.contributor.author | Offenbacher, S. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Clinical Periodontology, 2007; 34(4):285-293 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.issn | 1600-051X | - |
dc.identifier.uri | http://hdl.handle.net/2440/43081 | - |
dc.description | The definitive version is available at www.blackwell-synergy.com | - |
dc.description.abstract | Aim: Interleukin-1 β (IL-1β) and prostaglandin E2 (PGE2) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross-sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL-1β and PGE2 in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. Material and Methods: The sample comprised 6277 community-dwelling adults aged 52–74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL-1β and PGE2 concentrations were measured using enzyme-linked immunosorbent assay. Person-level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL-1β and PGE2 concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. Results: Both GCF IL-1β and PGE2 were positively related to MaxPD and BOP in multiple regression models (p<0.01). Increased levels of IL-1β and PGE2 were associated with body mass index 30 kg/m2. Conclusion: Higher levels of GCF IL-1β and PGE2 were significantly associated with clinical signs of periodontal disease and independently related to patient-based anthropomorphic measures, behaviours and exposures in community-dwelling adults. | - |
dc.description.statementofresponsibility | Y. Zhong, G. D. Slade, J. D. Beck and S. Offenbacher | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Munksgaard | - |
dc.source.uri | http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1600-051X.2007.01057.x | - |
dc.subject | Gingival Crevicular Fluid | - |
dc.subject | Humans | - |
dc.subject | Periodontal Diseases | - |
dc.subject | Dinoprostone | - |
dc.subject | Body Mass Index | - |
dc.subject | Periodontal Index | - |
dc.subject | Linear Models | - |
dc.subject | Least-Squares Analysis | - |
dc.subject | Cross-Sectional Studies | - |
dc.subject | Smoking | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Maryland | - |
dc.subject | North Carolina | - |
dc.subject | Minnesota | - |
dc.subject | Mississippi | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Interleukin-1beta | - |
dc.subject | Molecular Epidemiology | - |
dc.title | Gingival crevicular fluid interleukin-1β, prostaglandin E₂and periodontal status in a community population | - |
dc.title.alternative | Gingival crevicular fluid interleukin-1beta, prostaglandin E(2)and periodontal status in a community population | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1600-051X.2007.01057.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.