Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/43113
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Type: Journal article
Title: Supplementation with vitamins C, E, β-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial
Other Titles: Supplementation with vitamins C, E, beta-carotene and selenium has no effect on anti-oxidant status and immune responses in allergic adults: a randomized controlled trial
Author: Dunstan, J.
Breckler, L.
Hale, J.
Lehmann, H.
Franklin, P.
Lyons, G.
Ching, S.
Mori, T.
Barden, A.
Prescott, S.
Citation: Clinical and Experimental Allergy, 2007; 37(2):180-187
Publisher: Blackwell Science Ltd
Issue Date: 2007
ISSN: 0954-7894
1365-2222
Statement of
Responsibility: 
J. A. Dunstan, L. Breckler, J. Hale, H. Lehmann, P. Franklin, G. Lyons, S. Y. L. Ching, T. A. Mori, A. Barden and S. L. Prescott
Abstract: Background Anti-oxidants are of growing interest in early treatment and prevention of allergic diseases in early life, but the effects on allergen-specific immune responses need to be documented further before intervention studies in infants are undertaken. The aim of this study in adults was to determine the effects of dietary anti-oxidants on allergen-specific immune responses in sensitized individuals. Methods In a randomized controlled trial, 54 allergic adults received an anti-oxidant supplement (n=36) comprising β-carotene (9 mg/day), vitamin C (1500 mg/day), vitamin E (130 mg/day), zinc (45 mg/day), selenium (76 μg/day) and garlic (150 mg/day) or a placebo (n=18) for 4 weeks. Anti-oxidant capacity (AC), serum levels of vitamin C, vitamin E, β-carotene and selenium, peripheral blood responses, exhaled nitric oxide (eNO), as a marker of airway inflammation, and plasma F2 isoprostanes, as a measure of oxidative stress, were measured before and after supplementation. Results Anti-oxidant supplementation resulted in significant increases in serum levels of vitamin C, vitamin E, β-carotene and selenium levels, compared with the placebo group (P<0.001). There was no change in serum AC, plasma F2-isoprostanes, eNO or immune responses following supplementation with anti-oxidants compared with placebo. Conclusion Supplementation with anti-oxidants resulted in significantly increased levels of vitamin C, vitamin E, β-carotene and selenium but no change in immune responses, serum AC or plasma F2-isoprostanes.
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020070201
DOI: 10.1111/j.1365-2222.2007.02657.x
Appears in Collections:Agriculture, Food and Wine publications

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