Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||World Journal of Gastroenterology, 2007; 13(2):270-275||en|
|dc.description||Copyright © 2007 The WJG Press. All rights reserved.||en|
|dc.description.abstract||<h4>Aim</h4>To investigate the proximal gastric motor response to duodenal nutrients in critically ill patients with long-standing type 2 diabetes mellitus.<h4>Methods</h4>Proximal gastric motility was assessed (using a barostat) in 10 critically ill patients with type 2 diabetes mellitus (59 +/- 3 years) during two 60-min duodenal infusions of Ensure (1 and 2 kcal/min), in random order, separated by 2 h fasting. Data were compared with 15 non-diabetic critically ill patients (48 +/- 5 years) and 10 healthy volunteers (28 +/- 3 years).<h4>Results</h4>Baseline proximal gastric volumes were similar between the three groups. In diabetic patients, proximal gastric relaxation during 1 kcal/min nutrient infusion was similar to non-diabetic patients and healthy controls. In contrast, relaxation during 2 kcal/min infusion was initially reduced in diabetic patients (P < 0.05) but increased to a level similar to healthy humans, unlike non-diabetic patients where relaxation was impaired throughout the infusion. Duodenal nutrient stimulation reduced the fundic wave frequency in a dose-dependent fashion in both the critically ill diabetic patients and healthy subjects, but not in critically ill patients without diabetes. Fundic wave frequency in diabetic patients and healthy subjects was greater than in non-diabetic patients.<h4>Conclusion</h4>In patients with diabetes mellitus, proximal gastric motility is less disturbed than non-diabetic patients during critical illness, suggesting that these patients may not be at greater risk of delayed gastric emptying.||en|
|dc.description.statementofresponsibility||Nam Q Nguyen, Robert J Fraser, Laura K Bryant, Marianne Chapman, Richard H Holloway||en|
|dc.publisher||W J G Press||en|
|dc.subject||Duodenum; Humans; Diabetes Mellitus, Type 2; Critical Illness; Dietary Sucrose; Blood Glucose; Gastrointestinal Motility; Gastric Emptying; Food, Formulated; Adult; Middle Aged; Female; Male||en|
|dc.title||Proximal gastric motility in critically ill patients with type 2 diabetes mellitus||en|
|dc.identifier.orcid||Nguyen, Q. [0000-0002-1270-5441]||en|
|dc.identifier.orcid||Chapman, M. [0000-0003-0710-3283]||en|
|Appears in Collections:||Medicine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.