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Type: Journal article
Title: Glia: novel counter-regulators of opioid analgesia
Author: Watkins, L.
Hutchinson, M.
Johnston, I.
Maier, S.
Citation: Trends in Neurosciences, 2005; 28(12):661-669
Publisher: Elsevier Science London
Issue Date: 2005
ISSN: 0166-2236
Abstract: Development of analgesic tolerance and withdrawalinduced pain enhancement present serious difficulties for the use of opioids for pain control. Although neuronal mechanisms to account for these phenomena have been sought for many decades, their bases remain unresolved. Within the past four years, a novel nonneuronal candidate has been uncovered that opposes acute opioid analgesia and contributes to development of opioid tolerance and tolerance-associated pain enhancement. This novel candidate is spinal cord glia. Glia are important contributors to the creation of enhanced pain states via the release of neuroexcitatory substances. New data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Controlling glial activation could therefore increase the clinical utility of analgesic drugs.
Keywords: Brain
Spinal Cord
Neurotransmitter Agents
Analgesics, Opioid
Drug Tolerance
DOI: 10.1016/j.tins.2005.10.001
Appears in Collections:Aurora harvest
Earth and Environmental Sciences publications

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