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dc.contributor.authorChaikomin, R.en
dc.contributor.authorWu, K.en
dc.contributor.authorDoran, S.en
dc.contributor.authorSmout, A.en
dc.contributor.authorRenooij, W.en
dc.contributor.authorHolloway, R.en
dc.contributor.authorMeyer, J.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorRayner, C.en
dc.identifier.citationAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2007; 292(4):G1099-G1104en
dc.descriptionCopyright © 2007 by the American Physiological Society.en
dc.description.abstractUpper gastrointestinal motor function and incretin hormone secretion are major determinants of postprandial glycemia and insulinemia. However, the impact of small intestinal flow events on glucose absorption and incretin release is poorly defined. Intraluminal impedance monitoring is a novel technique that allows flow events to be quantified. Eight healthy volunteers were studied twice, in random order. A catheter incorporating six pairs of electrodes at 3-cm intervals, and six corresponding manometry sideholes, was positioned in the duodenum. Hyoscine butylbromide (20 mg) or saline was given as an intravenous bolus, followed by a continuous intravenous infusion of either hyoscine (20 mg/h) or saline over 60 min. Concurrently, glucose and 3-O-methylglucose (3-OMG) were infused into the proximal duodenum (3 kcal/min), with frequent blood sampling to measure glucose, 3-OMG, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The frequency of duodenal pressure waves and propagated pressure wave sequences was reduced by hyoscine in the first 10 min (P<0.01 for both), but not after that time. In contrast, there were markedly fewer duodenal flow events throughout 60 min with hyoscine (P<0.005). Overall, blood glucose (P<0.01) and plasma 3-OMG concentrations (P<0.05) were lower during hyoscine than saline, whereas plasma insulin, GLP-1, and GIP concentrations were initially (t=20 min) lower during hyoscine (P<0.05). In conclusion, intraluminal impedance measurement may be more sensitive than manometry in demonstrating alterations in duodenal motor function. A reduction in the frequency of duodenal flow events is associated with a decreased rate of glucose absorption and incretin release in healthy subjects.en
dc.description.statementofresponsibilityReawika Chaikomin, Keng Liang Wu, Selena Doran, Karen L. Jones, Andre J. P. M. Smout, Willem Renooij, Richard H. Holloway, James H. Meyer, Michael Horowitz, and Christopher K. Rayneren
dc.publisherAmer Physiological Socen
dc.subjectsmall intestine; anticholinergic; glucagon-like peptide-1; glucose-dependent insulinotropic polypeptideen
dc.titleConcurrent duodenal manometric and impedance recording to evaluate the effects of hyoscine on motility and flow events, glucose absorption, and incretin releaseen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
Appears in Collections:Medicine publications

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