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Type: Journal article
Title: Fetal exposure to herpesviruses may be associated with pregnancy-induced hypertensive disorders and preterm birth in a Caucasian population
Author: Gibson, C.
Goldwater, P.
MacLennan, A.
Haan, E.
Priest, K.
Dekker, G.
Citation: BJOG: an International Journal of Obstetrics and Gynaecology, 2008; 115(4):492-500
Publisher: Blackwell Publishing Ltd
Issue Date: 2008
ISSN: 1470-0328
Statement of
CS Gibson, PN Goldwater, AH MacLennan, EA Haan, K Priest, GA Dekker
Abstract: <h4>Objective</h4>To investigate the role of fetal viral infection in the development of a range of adverse pregnancy outcomes (APOs), including pregnancy-induced hypertensive disorders (PIHD), antepartum haemorrhage (APH), birthweight <10th percentile (small for gestational age, SGA) and preterm birth (PTB).<h4>Design</h4>Population-based case-control study.<h4>Setting</h4>Laboratory-based study.<h4>Population</h4>The newborn screening cards of 717 adverse pregnancy cases and 609 controls.<h4>Methods</h4>Newborn screening cards were tested for RNA from enteroviruses and DNA from herpesviruses using polymerase chain reaction (PCR). The herpesviruses were detected using two PCRs, one detecting nucleic acids from herpes simplex virus (HSV)-1, HSV-2, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and human herpesvirus (HHV)-8, hereafter designated Herpes PCR group A viruses, and the other detecting nucleic acids from varicella-zoster virus (VZV), HHV-6 and HHV-7, hereafter designated Herpes PCR group B viruses.<h4>Main outcome measure</h4>Odds ratios and 95% CIs for specific APOs.<h4>Results</h4>For both term and PTBs, the risk of developing PIHD was increased in the presence of DNA from Herpes PCR group B viruses (OR 3.57, 95% CI 1.10-11.70), CMV (OR 3.89, 95% CI 1.67-9.06), any herpesvirus (OR 5.70, 95% CI 1.85-17.57) and any virus (OR 5.17, 95% CI 1.68-15.94). The presence of CMV was associated with PTB (OR 1.61, 95% CI 1.14-2.27). No significant association was observed between SGA or APH and exposure to viral infection.<h4>Conclusions</h4>Fetal exposure to herpesvirus infection was associated with PIHD for both term and PTBs in this exploratory study. Exposure to CMV may also be associated with PTB. These findings need confirmation in future studies.
Keywords: Adverse pregnancy outcomes
fetal viral infection
pregnancy-induced hypertension
preterm birth.
Description: The definitive version is available at
DOI: 10.1111/j.1471-0528.2007.01653.x
Published version:
Appears in Collections:Aurora harvest
Cerebral Palsy Research Group publications
Obstetrics and Gynaecology publications

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