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https://hdl.handle.net/2440/43464
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Type: | Journal article |
Title: | Prevalence and significance of a negative extended-spectrum β-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program |
Other Titles: | Prevalence and significance of a negative extended-spectrum beta-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program |
Author: | Bell, J. Chitsaz, M. Turnidge, J. Barton, M. Walters, L. Jones, R. |
Citation: | Journal of Clinical Microbiology, 2007; 45(5):1478-1482 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2007 |
ISSN: | 0095-1137 1098-660X |
Statement of Responsibility: | Jan M. Bell, Mohsen Chitsaz, John D. Turnidge, Mary Barton, Luke J. Walters, and Ronald N. Jones |
Abstract: | A negative extended-spectrum beta-lactamase (ESBL) confirmation test result obtained after a positive ESBL screening test result using Clinical and Laboratory Standards Institute methods has been a common occurrence among isolates of Escherichia coli and Klebsiella pneumoniae in the SENTRY Antimicrobial Surveillance Program in the Asia-Pacific region. Among isolates collected between 1998 and 2004 this screen-positive, nonconfirmed profile (failed to show clavulanate synergy) was observed in 8.9% of 4,515 E. coli isolates and 20.3% of 2,303 K. pneumoniae isolates. We then selected 52 E. coli isolates and 68 K. pneumoniae isolates with a negative ESBL confirmation test, as well as comparable number of isolates with confirmed ESBL-positive tests, and examined them for the presence of TEM, SHV, plasmid-borne ampC, and CTX-M genes. We found that 62% of nonconfirming E. coli isolates and 75% of nonconfirming K. pneumoniae harbored a plasmid-borne AmpC enzyme of the CIT or DHA type. The majority of nonconfirming E. coli and K. pneumoniae from the Asia-Pacific region harbor important beta-lactamases, and a positive screening test alone should be sufficient grounds to report resistance to extended-spectrum cephalosporins in this region. |
Keywords: | Humans Escherichia coli Klebsiella pneumoniae Escherichia coli Infections Klebsiella Infections beta-Lactamases Anti-Bacterial Agents Population Surveillance Prevalence Sensitivity and Specificity beta-Lactam Resistance Asia |
Rights: | Copyright © 2007, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/JCM.02470-06 |
Published version: | http://dx.doi.org/10.1128/jcm.02470-06 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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