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|Title:||Prevalence and significance of a negative extended-spectrum β-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program|
|Other Titles:||Prevalence and significance of a negative extended-spectrum beta-lactamase (ESBL) confirmation test result after a positive ESBL screening test result for isolates of Escherichia coli and Klebsiella pneumoniae: Results from the SENTRY Asia-Pacific Surveillance Program|
|Citation:||Journal of Clinical Microbiology, 2007; 45(5):1478-1482|
|Publisher:||Amer Soc Microbiology|
|Jan M. Bell, Mohsen Chitsaz, John D. Turnidge, Mary Barton, Luke J. Walters, and Ronald N. Jones|
|Abstract:||A negative extended-spectrum beta-lactamase (ESBL) confirmation test result obtained after a positive ESBL screening test result using Clinical and Laboratory Standards Institute methods has been a common occurrence among isolates of Escherichia coli and Klebsiella pneumoniae in the SENTRY Antimicrobial Surveillance Program in the Asia-Pacific region. Among isolates collected between 1998 and 2004 this screen-positive, nonconfirmed profile (failed to show clavulanate synergy) was observed in 8.9% of 4,515 E. coli isolates and 20.3% of 2,303 K. pneumoniae isolates. We then selected 52 E. coli isolates and 68 K. pneumoniae isolates with a negative ESBL confirmation test, as well as comparable number of isolates with confirmed ESBL-positive tests, and examined them for the presence of TEM, SHV, plasmid-borne ampC, and CTX-M genes. We found that 62% of nonconfirming E. coli isolates and 75% of nonconfirming K. pneumoniae harbored a plasmid-borne AmpC enzyme of the CIT or DHA type. The majority of nonconfirming E. coli and K. pneumoniae from the Asia-Pacific region harbor important beta-lactamases, and a positive screening test alone should be sufficient grounds to report resistance to extended-spectrum cephalosporins in this region.|
|Keywords:||Humans; Escherichia coli; Klebsiella pneumoniae; Escherichia coli Infections; Klebsiella Infections; beta-Lactamases; Anti-Bacterial Agents; Population Surveillance; Prevalence; Sensitivity and Specificity; beta-Lactam Resistance; Asia|
|Rights:||Copyright © 2007, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Paediatrics publications|
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