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Type: Journal article
Title: Inter- and intra-subject variability in ethanol pharmacokinetic parameters: effects of testing interval and dose.
Author: Yelland, L.
Burns, J.
Sims, N.
Salter, A.
White, J.
Citation: Forensic Science International, 2008; 175(1):65-72
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2008
ISSN: 0379-0738
Statement of
Lisa N. Yelland, Jaimi P. Burns, D. Noel Sims, Amy B. Salter and Jason M. White
Abstract: Calculation of a blood alcohol concentration (BAC) at the time of an offence by forward or back-extrapolation, using population average values for ethanol pharmacokinetic parameters or a single estimate of individual specific parameters, ignores the possibility of inter- and intra-subject variability. In order to estimate inter- and intra-subject variability in the elimination rate and absorption rate, BAC was measured over time in 12 male volunteers on 4 occasions. Subjects received 0.44 g kg⁻¹ body weight of ethanol on the first study day, and 0.70 g kg⁻¹ body weight on subsequent study days 1, 11 and 12 weeks later, to enable comparisons in variability over short and long time periods and when the same or different doses were administered. Evidence of both inter- and intra-subject variability was found, with inter-subject variability substantially smaller than intra-subject variability when the dose varied. Forensically important differences in pharmacokinetic parameters were observed within individuals between occasions. These findings could have an important impact on medico-legal issues related to ethanol pharmacokinetics.
Keywords: Ethanol; Pharmacokinetics; Variability; Elimination rate; Absorption rate
Description: Copyright © 2007 Elsevier Ireland Ltd All rights reserved.
RMID: 0020080387
DOI: 10.1016/j.forsciint.2007.05.011
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