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Type: Journal article
Title: Insulin resistance increases the risk of spontaneous abortion after assisted reproduction technology treatment
Author: Tian, L.
Shen, H.
Lu, Q.
Norman, R.
Wang, J.
Citation: Journal of Clinical Endocrinology and Metabolism, 2007; 92(4):1430-1433
Publisher: Endocrine Society
Issue Date: 2007
ISSN: 0021-972X
Statement of
Li Tian, Huan Shen, Qun Lu, Robert J. Norman and Jim Wang
Abstract: <h4>Objective</h4>This study aims to examine the impact of insulin resistance (IR) on the risk of spontaneous abortion in patients who received infertility treatment.<h4>Patients and methods</h4>This is a cohort study of 107 patients who achieved their first pregnancy after infertility treatment in a tertiary medical center. A homeostasis model assessment of IR (HOMA-IR) was carried out. Patient demographic characteristics and pregnancy outcome were also recorded. Statistical comparison was made between patients with and without IR. Logistical regression analysis was used to assess the effect of IR and several other factors simultaneously on the risk of spontaneous abortion.<h4>Results</h4>The incidence of spontaneous abortion was 17.8%. The association of IR with the risk of spontaneous abortion was significant after adjusting for other risk factors. The effect of overweight/obesity and polycystic ovarian syndrome was not statistically significant in the multivariate model.<h4>Discussion and conclusion</h4>This study suggested that IR was an independent risk factor for spontaneous abortion. Because of the high prevalence of IR in obese or polycystic ovarian syndrome patients, the risk of spontaneous abortion in these patients can be raised. Patients with IR should be advised to improve their insulin sensitivity through lifestyle change or medical intervention before infertility treatment to reduce their risk of spontaneous abortion.
Keywords: Humans; Polycystic Ovary Syndrome; Abortion, Spontaneous; Insulin Resistance; Testosterone; Reproductive Techniques, Assisted; Embryo Transfer; Maternal Age; Pregnancy; Adult; Female
Description: Copyright © 2007 by The Endocrine Society
RMID: 0020070528
DOI: 10.1210/jc.2006-1123
Appears in Collections:Obstetrics and Gynaecology publications

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