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Type: Journal article
Title: Risk factors for lung cancer in patients with scleroderma: a nested case-control study
Author: Pontifex, E.
Hill, C.
Roberts-Thomson, P.
Citation: Annals of the Rheumatic Diseases, 2007; 66(4):551-553
Publisher: British Med Journal Publ Group
Issue Date: 2007
ISSN: 0003-4967
Statement of
Eliza K Pontifex, Catherine L Hill, Peter Roberts-Thomson
Abstract: Objectives: To study potential risk factors for the development of lung cancer in patients with scleroderma and explore the chronological relationship between onset of scleroderma symptoms and subtypes of lung cancer. Method: Linkage of two population-based registers to identify lung cancer cases and gender-matched controls with scleroderma, followed by retrospective case note review for clinical details. Results: Patients with scleroderma who smoke are seven times more likely to develop lung cancer than non-smokers (p = 0.008). Smokers with scleroderma and cancer smoke more than smokers with scleroderma without cancer (p = 0.019). Pulmonary fibrosis and anti-topoisomerase antibody do not increase the risk of lung cancer. Peripheral lung tumours occur earlier after the onset of scleroderma symptoms than bronchogenic tumours (p = 0.05). Conclusions: Smokers with scleroderma should be monitored for the presence of lung cancer and counselled to quit smoking. The earlier development of peripheral lung tumours is not consistent, with pulmonary fibrosis being an aetiological factor.
Keywords: Humans; Lung Neoplasms; Pulmonary Fibrosis; Scleroderma, Systemic; Scleroderma, Limited; Epidemiologic Methods; Smoking; Age of Onset; Time Factors; Aged; Middle Aged; South Australia; Female; Male
Description: Copyright © 2007 BMJ Publishing Group Ltd & European League Against Rheumatism
RMID: 0020076353
DOI: 10.1136/ard.2006.056424
Appears in Collections:Medicine publications

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