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Type: Journal article
Title: Stem cell regulation by lysophospholipids
Author: Pebay, A.
Bonder, C.
Pitson, S.
Citation: Prostaglandins and Other Lipid Mediators, 2007; 84(3-4):83-97
Publisher: Elsevier Inc.
Issue Date: 2007
ISSN: 1098-8823
Statement of
Alice Pébay, Claudine S. Bonder and Stuart M. Pitson
Abstract: Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) regulate a diverse range of mammalian cell processes, largely through engaging multiple G protein-coupled receptors specific for these lysophospholipids. LPA and S1P have been clearly identified to have widespread physiological and pathophysiological actions, controlling events within the reproductive, gastrointestinal, vascular, nervous and immune systems, and also having a prominent role in cancer. Here we review the recent literature showing the additional emerging role for LPA and S1P in the regulation of stem cells and their progenitors. We discuss the role of these lysophospholipids in regulating the proliferation, survival, differentiation and migration of a range of adult and embryonic stem cells and progenitors, and thus are likely to play a substantial role in the maintenance, generation, mobilisation and homing of stem cell and progenitor populations in the body.
Keywords: Stem Cells
Cell Differentiation
Cell Proliferation
Cell Movement
Cell Survival
Description: Copyright © 2007 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.prostaglandins.2007.08.004
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Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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