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dc.contributor.authorPilichiewicz, A.en
dc.contributor.authorChaikomin, R.en
dc.contributor.authorBrennan, I.en
dc.contributor.authorWishart, J.en
dc.contributor.authorRayner, C.en
dc.contributor.authorJones, K.en
dc.contributor.authorSmout, A.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorFeinle-Bisset, C.en
dc.identifier.citationAmerican Journal of Physiology-Endocrinology and Metabolism, 2007; 293(3):E743-E753en
dc.descriptionCopyright © 2007 by the American Physiological Society.en
dc.description.abstractGastric emptying is a major determinant of glycemia, gastrointestinal hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and cholecystokinin (CCK), antropyloroduodenal motility, and energy intake in healthy subjects. Blood glucose, plasma hormone, and antropyloroduodenal motor responses to 120-min intraduodenal infusions of glucose at 1) 1 ("G1"), 2) 2 ("G2"), and 3) 4 ("G4") kcal/min or of 4) saline ("control") were measured in 10 healthy males in double-blind, randomized fashion. Immediately after each infusion, energy intake at a buffet meal was quantified. Blood glucose rose in response to all glucose infusions (P < 0.05 vs. control), with the effect of G4 and G2 being greater than that of G1 (P < 0.05) but with no difference between G2 and G4. The rises in insulin, GLP-1, GIP, and CCK were related to the glucose load (r > 0.82, P < 0.05). All glucose infusions suppressed antral (P < 0.05), but only G4 decreased duodenal, pressure waves (P < 0.01), resulted in a sustained stimulation of basal pyloric pressure (P < 0.01), and decreased energy intake (P < 0.05). In conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, GLP-1, GIP and CCK, antropyloroduodenal motility, and energy intake in healthy subjects. These observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes.en
dc.description.statementofresponsibilityAmelia N. Pilichiewicz, Reawika Chaikomin, Ixchel M. Brennan, Judith M. Wishart, Christopher K. Rayner, Karen L. Jones, Andre J. P. M. Smout, Michael Horowitz, and Christine Feinle-Bisseten
dc.publisherAmer Physiological Socen
dc.subjectDuodenum; Pylorus; Humans; Insulin Resistance; Hormones; Insulin; Glucose; Energy Intake; Gastrointestinal Motility; Postprandial Period; Adult; Maleen
dc.titleLoad-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy menen
dc.typeJournal articleen
dc.provenanceFirst published July 3, 2007en
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidFeinle-Bisset, C. [0000-0001-6848-0125]en
Appears in Collections:Medicine publications

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