Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/43826
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Type: Journal article
Title: A randomised control trial examining the effect of an antioxidant (Menevit) on pregnancy outcome during IVF-ICSI treatment
Author: Tremellen, K.
Miari, G.
Froiland, D.
Thompson, J.
Citation: Australian & New Zealand Journal of Obstetrics & Gynaecology, 2007; 47(3):216-221
Publisher: Blackwell Publishing Asia
Issue Date: 2007
ISSN: 0004-8666
1479-828X
Statement of
Responsibility: 
Kelton Tremellen, George Miari, David Froiland and Jeremy Thompson
Abstract: Background: Evidence has accumulated supporting the role of reactive oxygen species (ROS) in the pathogenesis of sperm dysfunction among men with infertility. Damage to sperm DNA by ROS can lead to failure of conception, miscarriage or potentially even childhood cancer. The objective of this study was to examine the effect of male antioxidant treatment on embryo quality and pregnancy outcome during in vitro fertilisation-intracytoplasmic sperm injection (IVF-ICSI) treatment. Methods: Sixty couples with severe male factor infertility were enrolled in a prospective randomised double-blind placebo-controlled trial. Male participants were randomly assigned to take either one capsule per day of the Menevit antioxidant or an identical in appearance placebo for three months prior to their partner's IVF cycle. The primary outcome was cleavage stage embryo quality and the secondary outcomes were oocyte fertilisation rate, pregnancy rates and treatment side-effects. Approval by the local Human Research Ethics Committee was obtained prior to the commencement of this study. Results: The antioxidant group recorded a statistically significant improvement in viable pregnancy rate (38.5% of transferred embryos resulting in a viable fetus at 13 weeks gestation) compared to the control group (16% viable pregnancy). No significant changes in oocyte fertilisation rate or embryo quality were detected between the antioxidant and the placebo groups. Side-effects on the Menevit antioxidant were rare (8%) and mild in nature. Conclusions: The Menevit antioxidant appears to be a useful ancillary treatment that significantly improves pregnancy rates in couples undergoing IVF-ICSI treatment for severe male factor infertility.
Keywords: antioxidant; IVF-ICSI; oxidative stress; spermatozoa
Description: The definitive version is available at www.blackwell-synergy.com
RMID: 0020070783
DOI: 10.1111/j.1479-828X.2007.00723.x
Appears in Collections:Obstetrics and Gynaecology publications

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