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Type: Journal article
Title: To QC or not to QC: the key to a consistent laboratory?
Author: Lane, M.
Mitchell, M.
Cashman, K.
Inglis, D.
Wakefield, S.
Zander, D.
Citation: Reproduction Fertility and Development, 2008; 20(1):23-32
Publisher: C S I R O Publishing
Issue Date: 2008
ISSN: 1031-3613
Statement of
Michelle Lane, Megan Mitchell, Kara S. Cashman, Deanne Feil, Sarah Wakefield and Deirdre L. Zander-Fox
Abstract: A limiting factor in every embryology laboratory is its capacity to grow ‘normal’ embryos. In human in vitro fertilisation (IVF), there is considerable awareness that the environment of the laboratory itself can alter the quality of the embryos produced and the industry as a whole has moved towards the implementation of auditable quality management systems. Furthermore, in some countries, such as Australia, an established quality management system is mandatory for clinical IVF practice, but such systems are less frequently found in other embryology laboratories. Although the same challenges of supporting consistent and repeatable embryo development are paramount to success in all embryology laboratories, it could be argued that they are more important in a research setting where often the measured outcomes are at an intracellular or molecular level. In the present review, we have outlined the role and importance of quality control and quality assurance systems in any embryo laboratory and have highlighted examples of how simple monitoring can provide consistency and avoid the induction of artefacts, irrespective of the laboratory’s purpose, function or species involved.
Keywords: Blastocyst; Animals; Humans; Mice; Ammonia; Culture Media; Fertilization in Vitro; Embryo Culture Techniques; Embryology; Embryonic Development; Quality Control; Laboratories
Rights: © IETS 2008
RMID: 0020080091
DOI: 10.1071/RD07161
Published version:
Appears in Collections:Obstetrics and Gynaecology publications

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