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https://hdl.handle.net/2440/44126
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dc.contributor.author | Manakil, J. | - |
dc.contributor.author | Seymour, G. | - |
dc.contributor.author | Bartold, P. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Molecular Oral Microbiology, 2007; 22(4):272-276 | - |
dc.identifier.issn | 0902-0055 | - |
dc.identifier.issn | 1399-302X | - |
dc.identifier.uri | http://hdl.handle.net/2440/44126 | - |
dc.description.abstract | <h4>Introduction</h4>Cytokines are not only produced by activated lymphocytes but also interact with a number of cell-surface molecules on the same cells. Syndecan-1 is one such cell-surface molecule, which has the capacity to bind a variety of growth factors as well as cytokines. The aim of this study was to examine the effects of transforming growth factor beta (TGF-beta), interleukin-1 (IL-1), IL-2, IL-4, lipopolysaccharide (LPS) from Porphyromonas gingivalis and tetanus toxoid on syndecan-1 expression by B and T lymphocytes.<h4>Methods</h4>B and T lymphocytes were obtained from the peripheral blood of healthy donors. Following exposure to the above growth factors, cytokines and antigens, syndecan-1 expression was determined by flow cytometry.<h4>Results</h4>Subjects could be categorized as high or low expressors of syndecan-1. In the high-responder group TGF-beta1 alone resulted in a significant increase in syndecan-1 expression by both B and T cells. None of the other cytokines and antigens produced a significant response. When analysed in combination, TGF-beta1 in combination with IL-2, IL-4, P. gingivalis LPS and tetanus toxoid all produced significant increases in syndecan-1 expression by B cells. For T cells, combinations of TGF-beta1 with IL-2 and tetanus toxoid resulted in increased syndecan-1 expression.<h4>Conclusions</h4>Both B and T lymphocytes synthesize the cell-surface proteoglycan syndecan-1 and its expression can be modulated by TGF-beta1, either alone or in combination with IL-2, IL-4 and LPS from P. gingivalis and tetanus toxoid. While these may reflect general responses under inflammatory conditions their biological significance requires further investigation. | - |
dc.description.statementofresponsibility | J. F. Manakil, G. J. Seymour, P. M. Bartold | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Munksgaard | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1399-302x.2007.00356.x | - |
dc.subject | Lymphocytes | - |
dc.subject | Cells, Cultured | - |
dc.subject | Humans | - |
dc.subject | Recombinant Proteins | - |
dc.subject | Antigens, Bacterial | - |
dc.subject | Cytokines | - |
dc.subject | Drug Combinations | - |
dc.subject | Analysis of Variance | - |
dc.subject | Regression Analysis | - |
dc.subject | Lymphocyte Activation | - |
dc.subject | Gene Expression Regulation | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Transforming Growth Factor beta1 | - |
dc.subject | Syndecan-1 | - |
dc.title | Effect of cytokine and antigen stimulation on peripheral blood lymphocyte syndecan-1 expression | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1399-302X.2007.00356.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Bartold, P. [0000-0002-5695-3877] | - |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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