Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44292
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment
Author: Caroli, A.
Testa, C.
Geroldi, C.
Nobili, F.
Barnden, L.
Guerra, U.
Bonetti, M.
Frisoni, G.
Citation: Journal of Neurology, 2007; 254(12):1698-1707
Publisher: Dr Dietrich Steinkopff Verlag
Issue Date: 2007
ISSN: 0340-5354
1432-1459
Statement of
Responsibility: 
A. Caroli, C. Testa, C. Geroldi, F. Nobili, L. R. Barnden, U. P. Guerra, M. Bonetti and G. B. Frisoni
Abstract: Objective Aim of this study was to find cerebral perfusion correlates of conversion to dementia in patients with amnestic MCI. Methods 17 healthy subjects (age = 69 ± 3, 9 females), and 23 amnestic MCI patients (age = 70 ± 6, 10 females) underwent brain MR scan and 99mTc ECD SPECT. Conversion to AD was ascertained on average 19 ± 10 months after baseline: 9 had converted (age = 69 ± 3, 4 females), and 14 had not (age = 71 ± 8, 6 females). We processed SPECT images with SPM2 following an optimized protocol and performed a voxel-based statistical analysis comparing amnestic MCI patients converted to AD and non-converted to dementia vs controls. We assessed the effect of gray matter atrophy on the above results with SPM2 using an optimized Voxel-Based Morphometry (VBM) protocol.We compared significant hypoperfusion with significant atrophy on a voxel-byvoxel basis. Results In comparison with normal controls, amnestic MCI patients who converted to AD showed hypoperfusion in the right parahippocampal gyrus and left inferior temporal and fusiform gyri,whereas those who did not convert showed hypoperfusion in the retrosplenial cortex, precuneus and occipital gyri, mainly on the left side.We found no overlap between significant atrophy and significant hypoperfusion regions. Conclusions Parahippocampal and inferior temporal hypoperfusion in amnestic MCI patients appears as a correlate of conversion to AD; hypoperfusion in the retrosplenial cortex is involved in memory impairment but does not seem the key prognostic indicator of conversion to dementia.
Keywords: mild cognitive impairment; conversion; SPECT; SPET
Description: The original publication can be found at www.springerlink.com
RMID: 0020073189
DOI: 10.1007/s00415-007-0631-7
Appears in Collections:Chemistry and Physics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.