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Type: Journal article
Title: Gastric feed intolerance is not increased in critically ill patients with type II diabetes mellitus
Author: Nguyen, Q.
Lam, S.
Ching, K.
Chapman, M.
Fraser, R.
Holloway, R.
Citation: Intensive Care Medicine, 2007; 33(10):1740-1745
Publisher: Springer
Issue Date: 2007
ISSN: 0342-4642
Statement of
N. Q. Nguyen, S. W. Lam, K. Ching, M. Chapman, R. J. Fraser and R. H. Holloway
Abstract: <h4>Objective</h4>To examine the occurrence of feed intolerance in critically ill patients with previously diagnosed type II diabetes mellitus (DM) who received prolonged gastric feeding.<h4>Design and setting</h4>Retrospective study in a level 3 mixed ICU.<h4>Patients</h4>All mechanically ventilated, enterally fed patients (n = 649), with (n = 118) and without type II DM (n = 531) admitted between January 2003 and July 2005.<h4>Interventions</h4>Patients with at least 72 h of gastric feeding were identified by review of case notes and ICU charts. The proportion that developed feed intolerance was determined. All patient received insulin therapy.<h4>Results</h4>The proportion of patients requiring gastric feeding for at least 72 h was similar between patients with and without DM (42%, 50/118, vs. 42%, 222/531). Data from patients with DM were also compared with a group of 50 patients matched for age, sex and APACHE II score, selected from the total non-diabetic group. The occurrence of feed intolerance (DM 52% vs. matched non-DM 50% vs. unselected non-diabetic 58%) and the time taken to develop feed intolerance (DM 62.6 +/- 43.8 h vs. matched non-DM 45.3 +/- 54.6 vs. unselected non-diabetic 50.6 +/- 59.5) were similar amongst the three groups. Feed intolerance was associated with a greater use of morphine/midazolam and vasopressor support, a lower feeding rate and a longer ICU length of stay.<h4>Conclusions</h4>In critically ill patients who require prolonged enteral nutrition, a prior history of DM type II does not appear to be a further risk factor for feed intolerance.
Keywords: Diabetes mellitus
Gastric feed intolerance
Critically ill
Description: © Springer The original publication can be found at
Provenance: An erratum to this article can be found at
DOI: 10.1007/s00134-007-0712-1
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