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https://hdl.handle.net/2440/44366
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Robertson, S. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Cytokine and Growth Factor Reviews, 2007; 18(3-4):287-298 | - |
dc.identifier.issn | 1359-6101 | - |
dc.identifier.issn | 1879-0305 | - |
dc.identifier.uri | http://hdl.handle.net/2440/44366 | - |
dc.description | Copyright © 2007 Elsevier Ltd All rights reserved. | - |
dc.description.abstract | The reproductive tissues undergo profound structural changes and major immune adaptation to accommodate pregnancy. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestational tissues synthesise GM-CSF under direction by ovarian steroid hormones and signalling agents originating in male seminal fluid and the conceptus. The pre-implantation embryo, invading placental trophoblast cells and the abundant populations of leukocytes controlling maternal immune tolerance are all subject to GM-CSF regulation. GM-CSF deficiency in pregnancy adversely impacts fetal and placental development, as well as progeny viability and growth after birth, highlighting this cytokine as a central maternal determinant of pregnancy outcome with clinical relevance in human fertility. | - |
dc.description.statementofresponsibility | Sarah A. Robertson | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/j.cytogfr.2007.04.008 | - |
dc.subject | Ovary | - |
dc.subject | Leukocytes | - |
dc.subject | Blastocyst | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Steroids | - |
dc.subject | Hormones | - |
dc.subject | Granulocyte-Macrophage Colony-Stimulating Factor | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Cell Lineage | - |
dc.subject | Pregnancy | - |
dc.subject | Models, Biological | - |
dc.subject | Female | - |
dc.subject | Embryo, Mammalian | - |
dc.title | GM-CSF regulation of embryo development and pregnancy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.cytogfr.2007.04.008 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Robertson, S. [0000-0002-9967-0084] | - |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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