Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44594
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Type: Journal article
Title: A high-fat diet raises fasting plasma CCK, but does not affect upper gut motility, PYY and ghrelin, or energy intake during CCK-8 infusion in lean men
Author: Little, T.
Feltrin, K.
Horowitz, M.
Meyer, J.
Wishart, J.
Chapman, I.
Feinle-Bisset, C.
Citation: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2008; 294(1):WWW 1-WWW 31
Publisher: Amer Physiological Soc
Issue Date: 2008
ISSN: 0363-6119
1522-1490
Statement of
Responsibility: 
Tanya J. Little, Kate L. Feltrin, Michael Horowitz, James H. Meyer, Judith Wishart, Ian M. Chapman, and Christine Feinle-Bisset
Abstract: There is evidence from studies in animals that the effects of both fat and CCK on gastrointestinal function and energy intake are attenuated by consumption of a high-fat diet. In humans, the effects of exogenous CCK-8 on antropyloroduodenal motility, plasma CCK, peptide YY (PYY), and ghrelin concentrations, appetite, and energy intake are attenuated by a high-fat diet. Ten healthy lean males consumed isocaloric diets (~15,400 kJ per day), containing either 44% (high-fat, HF) or 9% (low-fat, LF) fat, for 21 days in single-blind, randomized, cross-over fashion. Immediately following each diet (i.e., on day 22), subjects received a 45-min intravenous infusion of CCK-8 (2 ng.kg(-1).min(-1)), and effects on antropyloroduodenal motility, plasma CCK, PYY, ghrelin concentrations, hunger, and fullness were determined. Thirty minutes after commencement of the infusion, subjects were offered a buffet-style meal, from which energy intake (in kilojoules) was quantified. Body weight was unaffected by the diets. Fasting CCK (P < 0.05), but not PYY and ghrelin, concentrations were greater following the HF, compared with the LF, diet. Infusion of CCK-8 stimulated pyloric pressures (P < 0.01) and suppressed antral and duodenal pressures (P < 0.05), with no difference between the diets. Energy intake also did not differ between the diets. Short-term consumption of a HF diet increases fasting plasma CCK concentrations but does not affect upper gut motility, PYY and ghrelin, or energy intake during CCK-8 infusion, in a dose of 2 ng.kg(-1).min(-1), in healthy males.
Keywords: antropyloroduodenal motility; appetite; gut hormones; healthy subjects
Description: Copyright © 2008 by the American Physiological Society.
RMID: 0020073178
DOI: 10.1152/ajpregu.00597.2007
Published version: http://ajpregu.physiology.org/cgi/content/abstract/294/1/R45
Appears in Collections:Medicine publications

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