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https://hdl.handle.net/2440/44603
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Type: | Journal article |
Title: | Attenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia. |
Author: | Baulk, S. Biggs, S. Reid, K. van den Heuvel, C. Drew, D. |
Citation: | Sleep, 2006; 29(9):1174-1180 |
Publisher: | Amer Academy Sleep Medicine |
Issue Date: | 2006 |
ISSN: | 0161-8105 1550-9109 |
Abstract: | STUDY OBJECTIVES: To determine if heat loss capacity of sleep onset insomniacs was different from that of healthy sleepers. DESIGN: Measure skin temperature responses following brief exposure to a warm peripheral thermal challenge (PTC). SETTING: Sleep research laboratory in South Australia. PARTICIPANTS: Eight primary insomniacs with sleep onset insomnia according to DSM-IV-TR criteria (SOI; 5 male, 3 female; mean age +/- SEM = 35.2 +/- 4.2 years) and ten healthy sleeping control subjects (HS; 7 male, 3 female; mean age = 28.2 +/- 2.8 years). INTERVENTIONS: Two PTC conditions in counterbalanced order on non-consecutive days. During each condition, the subject's non-dominant forearm and hand were immersed for 3 minutes in Warm (45 degrees C) or Control water (i.e. same as the subject's non-dominant index finger temperature just prior to immersion, range 30-35 degrees C). MEASUREMENTS AND RESULTS: HS had a significantly higher maximum finger temperature response after immersion than SOI (P < 0.05). Expressed relative to Control PTC temperatures, the Warm PTC caused a significant increase in mean finger temperature for HS of 4.1 +/- 0.8 degrees C, compared with SOI of 0.9 +/- 0.4 degrees C. A significant negative relationship was observed between maximum finger temperature response and self-reported sleep onset latencies (R = -0.57, P < 0.05). There were no main effects of sleep status (SOI vs. HS) or interactions by time, in skin temperatures measured at either the back of hands or feet. CONCLUSIONS: SOI were observed to have significantly attenuated thermoregulatory responses to a mild positive thermal challenge, providing evidence that impaired heat loss capacity from the periphery is associated with sleep onset insomnia. |
Keywords: | Neurological disorder Nervous system diseases Sleep disorder Sleep wake cycle Human Insomnia Sleep Thermoregulation |
DOI: | 10.1093/sleep/29.9.1174 |
Description (link): | http://direct.bl.uk/bld/PlaceOrder.do?UIN=195469305&ETOC=RN&from=searchengine |
Published version: | http://dx.doi.org/10.1093/sleep/29.9.1174 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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