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Type: Journal article
Title: Attenuated thermoregulatory response to mild thermal challenge in subjects with sleep-onset insomnia.
Author: Baulk, S.
Biggs, S.
Reid, K.
van den Heuvel, C.
Drew, D.
Citation: Sleep, 2006; 29(9):1174-1180
Publisher: Amer Academy Sleep Medicine
Issue Date: 2006
ISSN: 0161-8105
Abstract: STUDY OBJECTIVES: To determine if heat loss capacity of sleep onset insomniacs was different from that of healthy sleepers. DESIGN: Measure skin temperature responses following brief exposure to a warm peripheral thermal challenge (PTC). SETTING: Sleep research laboratory in South Australia. PARTICIPANTS: Eight primary insomniacs with sleep onset insomnia according to DSM-IV-TR criteria (SOI; 5 male, 3 female; mean age +/- SEM = 35.2 +/- 4.2 years) and ten healthy sleeping control subjects (HS; 7 male, 3 female; mean age = 28.2 +/- 2.8 years). INTERVENTIONS: Two PTC conditions in counterbalanced order on non-consecutive days. During each condition, the subject's non-dominant forearm and hand were immersed for 3 minutes in Warm (45 degrees C) or Control water (i.e. same as the subject's non-dominant index finger temperature just prior to immersion, range 30-35 degrees C). MEASUREMENTS AND RESULTS: HS had a significantly higher maximum finger temperature response after immersion than SOI (P < 0.05). Expressed relative to Control PTC temperatures, the Warm PTC caused a significant increase in mean finger temperature for HS of 4.1 +/- 0.8 degrees C, compared with SOI of 0.9 +/- 0.4 degrees C. A significant negative relationship was observed between maximum finger temperature response and self-reported sleep onset latencies (R = -0.57, P < 0.05). There were no main effects of sleep status (SOI vs. HS) or interactions by time, in skin temperatures measured at either the back of hands or feet. CONCLUSIONS: SOI were observed to have significantly attenuated thermoregulatory responses to a mild positive thermal challenge, providing evidence that impaired heat loss capacity from the periphery is associated with sleep onset insomnia.
Keywords: Neurological disorder; Nervous system diseases; Sleep disorder; Sleep wake cycle; Human; Insomnia; Sleep; Thermoregulation
RMID: 0020077165
DOI: 10.1093/sleep/29.9.1174
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Appears in Collections:Obstetrics and Gynaecology publications

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