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https://hdl.handle.net/2440/4479
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Type: | Journal article |
Title: | Formation of metallo-6A-((2-(bis(2-aminoethyl)amino)ethyl)amino)-6A-deoxy-b-cyclodextrins and their complexation of tryptophan in aqueous solution |
Author: | Lincoln, S. Haskard, C. Easton, C. May, B. |
Citation: | Inorganic Chemistry: including bioinorganic chemistry, 1996; 35(4):1059-1064 |
Publisher: | AMER CHEMICAL SOC |
Issue Date: | 1996 |
ISSN: | 0020-1669 1520-510X |
Abstract: | A pH titration study shows that 6(A)-((2-(bis(2-aminoethyl)amino)ethyl)amino)-6(A)-deoxy-beta-cyclodextrin (betaCDtren) forms binary metallocyclodextrins, [M(betaCDtren)](2+), for which log(K/dm(3) mol(-)(1)) = 11.65 +/- 0.06, 17.29 +/- 0.05, and 12.25 +/- 0.03, respectively, when M(2+) = Ni(2+), Cu(2+), and Zn(2+), where K is the stability constant in aqueous solution at 298.2 K and I = 0.10 mol dm(-)(3) (NaClO(4)). The ternary metallocyclodextrins [M(betaCDtren)Trp](+), where Trp(-) is the tryptophan anion, are characterized by log(K/dm(3) mol(-)(1)) = 8.2 +/- 0.2 and 8.1 +/- 0.2, 9.5 +/- 0.3 and 9.4 +/- 0.2, and 8.1 +/- 0.1 and 8.3 +/- 0.1, respectively, where the first and second values represent the stepwise stability constants for the complexation of (R)- and (S)-Trp(-), respectively, when M(2+) = Ni(2+), Cu(2+), and Zn(2+). From comparisons of stabilities and UV-visible spectra, the binary and ternary metallocyclodextrins appear to be six-coordinate when M(2+) = Ni(2+) and Zn(2+) and five-coordinate when M(2+) = Cu(2+). The factors affecting the stoichiometries and stabilities of the metallocyclodextrins, are discussed and comparisons are made with related systems. |
DOI: | 10.1021/ic9510831 |
Published version: | http://dx.doi.org/10.1021/ic9510831 |
Appears in Collections: | Aurora harvest 6 Chemistry publications Environment Institute publications |
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