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dc.contributor.authorGobel, R.en
dc.contributor.authorSymonds, E.en
dc.contributor.authorButler, R.en
dc.contributor.authorTran, C.en
dc.identifier.citationDigestive Diseases and Sciences, 2007; 52(11):3049-3053en
dc.descriptionThe original publication can be found at www.springerlink.comen
dc.description.abstractHelicobacter pylori infection may cause intrauterine growth restriction (IUGR). However, it is unknown whether the growth of children from H. pylori-infected mothers is also affected or whether transmission of infection from mother to child occurs. This study aimed to determine if maternal H. pylori infection was associated with IUGR and low birth weight in a mouse model, and whether transmission of infection from mother to infant occurs. Female C57BL/6 mice were inoculated with H. pylori (n = 18) or water (control; n = 18) via gavage. Mice were mated at 6 weeks postinfection, with half of the mice sacrificed after 2 weeks of gestation. The remaining mice gave birth and a third of the litter was weighed and sacrificed at birth, during milk feeding (1.5 weeks), and during solid feeding (4 weeks). Stomachs of all mice and whole foetuses were cultured for the presence of H. pylori. There were no differences in litter size or foetus weight between control and H. pylori-infected mice. Pups from infected mothers had a lower weight during milk feeding (control, 5.91 ± 0.23 g; H. pylori, 4.59 ± 0.16 g; p < 0.05) and solid feeding (control, 12.73 ± 0.58 g; H. pylori, 10.01 ± 1.02 g; p < 0.05). H. pylori was not detected by culture in the pups at any age. H. pylori infection in mothers was associated with a decrease in infant weight during milk feeding and after weaning. Transmission of infection from mother to infant was not detected by culture, suggesting that decreased baby weight may be due to decreased milk supply or altered nutrition from the mother.en
dc.description.statementofresponsibilityRikke Gøbel, Erin L. Symonds, Ross N. Butler and Cuong D. Tranen
dc.publisherKluwer Academic/Plenum Publen
dc.subjectHelicobacter pylori; Birth weight; Transmission; Mouse modelen
dc.titleAssociation between Helicobacter pylori Infection in mothers and birth weighten
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
dc.identifier.orcidTran, C. [0000-0001-9220-2715]en
Appears in Collections:Molecular and Biomedical Science publications

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