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|Title:||Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut|
|Citation:||Journal of Virology, 2007; 81(15):8025-8029|
|Publisher:||Amer Soc Microbiology|
|David P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport|
|Abstract:||CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.|
|Keywords:||Gastrointestinal Tract; CD4-Positive T-Lymphocytes; Animals; Macaca mulatta; Humans; Simian Acquired Immunodeficiency Syndrome; Receptors, CCR5; Viral Load; Mathematics; Models, Theoretical; Simian immunodeficiency virus|
|Provenance:||Published ahead of print on 16 May 2007.|
|Rights:||© 2007, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Molecular and Biomedical Science publications|
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