Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44836
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Type: Journal article
Title: Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut
Author: Wilson, D.
Mattapallil, J.
Lay, M.
Zhang, L.
Roederer, M.
Davenport, M.
Citation: Journal of Virology, 2007; 81(15):8025-8029
Publisher: Amer Soc Microbiology
Issue Date: 2007
ISSN: 0022-538X
1098-5514
Statement of
Responsibility: 
David P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport
Abstract: CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
Keywords: Gastrointestinal Tract; CD4-Positive T-Lymphocytes; Animals; Macaca mulatta; Humans; Simian Acquired Immunodeficiency Syndrome; Receptors, CCR5; Viral Load; Mathematics; Models, Theoretical; Simian immunodeficiency virus
Provenance: Published ahead of print on 16 May 2007.
Rights: © 2007, American Society for Microbiology. All Rights Reserved.
RMID: 0020076850
DOI: 10.1128/JVI.01771-06
Appears in Collections:Molecular and Biomedical Science publications

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