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https://hdl.handle.net/2440/44836
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Wilson, D. | - |
dc.contributor.author | Mattapallil, J. | - |
dc.contributor.author | Lay, M. | - |
dc.contributor.author | Zhang, L. | - |
dc.contributor.author | Roederer, M. | - |
dc.contributor.author | Davenport, M. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Virology, 2007; 81(15):8025-8029 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.issn | 1098-5514 | - |
dc.identifier.uri | http://hdl.handle.net/2440/44836 | - |
dc.description.abstract | CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo. | - |
dc.description.statementofresponsibility | David P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Microbiology | - |
dc.rights | © 2007, American Society for Microbiology. All Rights Reserved. | - |
dc.source.uri | http://dx.doi.org/10.1128/jvi.01771-06 | - |
dc.subject | Gastrointestinal Tract | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | Animals | - |
dc.subject | Macaca mulatta | - |
dc.subject | Humans | - |
dc.subject | Simian Acquired Immunodeficiency Syndrome | - |
dc.subject | Receptors, CCR5 | - |
dc.subject | Viral Load | - |
dc.subject | Mathematics | - |
dc.subject | Models, Theoretical | - |
dc.subject | Simian immunodeficiency virus | - |
dc.title | Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut | - |
dc.type | Journal article | - |
dc.provenance | Published ahead of print on 16 May 2007. | - |
dc.identifier.doi | 10.1128/JVI.01771-06 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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