Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/44836
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dc.contributor.authorWilson, D.-
dc.contributor.authorMattapallil, J.-
dc.contributor.authorLay, M.-
dc.contributor.authorZhang, L.-
dc.contributor.authorRoederer, M.-
dc.contributor.authorDavenport, M.-
dc.date.issued2007-
dc.identifier.citationJournal of Virology, 2007; 81(15):8025-8029-
dc.identifier.issn0022-538X-
dc.identifier.issn1098-5514-
dc.identifier.urihttp://hdl.handle.net/2440/44836-
dc.description.abstractCD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.-
dc.description.statementofresponsibilityDavid P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport-
dc.language.isoen-
dc.publisherAmer Soc Microbiology-
dc.rights© 2007, American Society for Microbiology. All Rights Reserved.-
dc.source.urihttp://dx.doi.org/10.1128/jvi.01771-06-
dc.subjectGastrointestinal Tract-
dc.subjectCD4-Positive T-Lymphocytes-
dc.subjectAnimals-
dc.subjectMacaca mulatta-
dc.subjectHumans-
dc.subjectSimian Acquired Immunodeficiency Syndrome-
dc.subjectReceptors, CCR5-
dc.subjectViral Load-
dc.subjectMathematics-
dc.subjectModels, Theoretical-
dc.subjectSimian immunodeficiency virus-
dc.titleEstimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut-
dc.typeJournal article-
dc.provenancePublished ahead of print on 16 May 2007.-
dc.identifier.doi10.1128/JVI.01771-06-
pubs.publication-statusPublished-
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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