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Type: Journal article
Title: Type III secretion à la Chlamydia
Other Titles: Type III secretion a la Chlamydia
Author: Peters, J.
Wilson, D.
Myers, G.
Timms, P.
Bavoil, P.
Citation: Trends in Microbiology, 2007; 15(6):241-251
Publisher: Elsevier Science London
Issue Date: 2007
ISSN: 0966-842X
Statement of
Jan Peters, David P. Wilson, Garry Myers, Peter Timms and Patrik M. Bavoil
Abstract: Type III secretion (T3S) is a mechanism that is central to the biology of the Chlamydiaceae and many other pathogens whose virulence depends on the translocation of toxic effector proteins to cytosolic targets within infected eukaryotic cells. Biomathematical simulations, using a previously described model of contact-dependent, T3S-mediated chlamydial growth and late differentiation, suggest that chlamydiae contained in small non-fusogenic inclusions will persist. Here, we further discuss the model in the context of in vitro-persistent, stress-induced aberrantly enlarged forms and of recent studies using small molecule inhibitors of T3S. A general mechanism is emerging whereby both early- and mid-cycle T3S-mediated activities and late T3S inactivation upon detachment of chlamydiae from the inclusion membrane are crucial for chlamydial intracellular development.
Keywords: Eukaryotic Cells
Chlamydia Infections
Bacterial Proteins
Membrane Proteins
Virulence Factors
Protein Transport
Genes, Bacterial
Multigene Family
Models, Biological
DOI: 10.1016/j.tim.2007.04.005
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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